A6706
O-乙酰基-L-肉碱盐酸盐 盐酸盐
≥99% (titration)
别名:
(R)-3-乙酰氧基-4-（三甲基铵）丁酸酯 盐酸盐, 乙酰 L-肉碱盐酸盐, ALC, ALCAR, R-(-)-2-乙酰氧基-3-羧基- N,N,N -三甲基-1-丙胺氯化物
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C9H17NO4 · HCl
化学文摘社编号:
分子量:
239.70
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
MDL number:
Beilstein/REAXYS Number:
4340103
产品名称
O-乙酰基-L-肉碱盐酸盐 盐酸盐, ≥99% (titration), powder
biological source
synthetic
SMILES string
C[N+](C)(C)C[C@H](OC(C)=O)CC(O)=O.[Cl-]
InChI key
JATPLOXBFFRHDN-DDWIOCJRSA-N
InChI
1S/C9H17NO4.ClH/c1-7(11)14-8(5-9(12)13)6-10(2,3)4;/h8H,5-6H2,1-4H3;1H/t8-;/m1./s1
assay
≥99% (titration)
form
powder
optical activity
[α]25/D −28°, c = 2 in H2O(lit.)
color
white to off-white
mp
194 °C
solubility
H2O: 100 mg/mL
application(s)
cell analysis
storage temp.
2-8°C
Quality Level
正在寻找类似产品? 访问 产品对比指南
Biochem/physiol Actions
通过线粒体膜转运乙酰基的内源性线粒体代谢物。
乙酰左旋肉碱(ALC)在中间代谢和提高女性生育力中起重要作用。女性生殖系统的氧化和代谢状态受到ALC调控。ALC具有拟胆碱和抗炎功效。它可调控γ-氨基丁酸(GABA)系统。ALC能调节大脑的葡萄糖利用率。ALC对发育大脑具有神经保护作用。
通过线粒体膜转运乙酰基的内源性线粒体代谢物。外源性乙酰肉碱增强老年大鼠线粒体功能。作为辅酶 A 的醋酸盐供体，增加中枢和外周乙酰胆碱合成和功能。乙酰肉碱具有抗伤害感受性活性，可能通过增强毒蕈碱胆碱能受体或 mGlu2 谷氨酸受体的活性介导。
Application
O-乙酰-L-肉碱盐酸盐已用于：
- 作为生物活性分子体外研究其对B淋巴母细胞样细胞系(BLCL)增殖的影响以及对流感病毒特异性人B和T细胞免疫应答的调节作用
- 作为体外成熟(IVM)培养基组分，研究其对羔羊卵母细胞囊胚率、超微结构和线粒体DNA拷贝数的影响
- 作为代谢物/化学标准品对鼠肿瘤组织间液中的代谢物水平进行定量分析
General description
乙酰-L-肉碱(ALC/ALCAR)是一种类维生素，作为肉碱代谢物存在于哺乳动物血浆和组织中。它是L-肉碱(LC)的乙酰形式。ALCAR可用作膳食补充剂。它以高浓度存在于下丘脑中。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Kifayatullah Shah et al.
Drug delivery, 24(1), 1631-1647 (2017-10-25)
The study investigated aerosolization, pulmonary inhalation, intracellular trafficking potential in macrophages and pharmacokinetics profiles of rifampicin-oleic acid first-generation nanoemulsion and its respective chitosan- and chitosan-folate conjugate-decorated second and third-generation nanoemulsions, delivered via nebulization technique. The nanoemulsions were prepared by conjugate
Rosa Palmeri et al.
Foods (Basel, Switzerland), 9(2) (2020-02-27)
Consumer interest toward natural ingredients is creating a growing trend in the food industry and research for the development of natural products such as colorants, antimicrobials and antioxidants. Semi-processed frozen prickly pear (Opuntia ficus-indica (L.) Mill.) juices (PPJs), obtained from
Abbi D Lane-Cordova et al.
PloS one, 12(10), e0186495-e0186495 (2017-10-20)
Having experienced 2-3 births is associated with reduced mortality versus women with <2 or ≥4 births. The effect of 2-3 births on lifespan may be associated with delayed cellular aging. We hypothesized telomere length, a marker of cellular aging, would
Effects of acetyl-L-carnitine on lamb oocyte blastocyst rate, ultrastructure, and mitochondrial DNA copy number
Reader KL, et al.
Theriogenology, 83(9), 1484-1492 (2015)
Barbara De Santis et al.
Nutritional neuroscience, 22(2), 132-144 (2017-08-11)
Objectives: Gene-environment interaction is an emerging hypothesis to expound not only the autism pathogenesis but also the increased incidence of neurodevelopmental disorders (such as autistic spectrum disorder, attention-deficit, hyperactivity disorder). Among xenobiotics, mycotoxins are worldwide contaminants of food that provoke
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持