A6719
ω-Agatoxin IVA
≥90% (HPLC)
别名:
SNX 290
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关于此项目
经验公式（希尔记法）:
C217H360N68O60S10
化学文摘社编号:
分子量:
5202.25
UNSPSC Code:
12352200
NACRES:
NA.28
MDL number:
Quality Segment
assay
≥90% (HPLC)
form
powder
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
Gene Information
human ... CACNA1A(773)
mouse ... CACNA1A(12286)
rat ... CACNA1A(25398)
General description
CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene codes for the α1 subunit of neuronal CaV2.1 (P/Q-type) voltage-gated calcium channels. It is expressed throughout the central nervous system (CNS). CACNA1A gene is located on human chromosome 19p13.
Application
ω-Agatoxin IVA has been used in the manipulation of calcium influx. It has also been used in the study to characterize the spontaneous and evoked activity from murine ventral horn cultures on microelectrode arrays.
Biochem/physiol Actions
Mutations in the CACNA1A (calcium voltage-gated channel subunit alpha1 A) gene is responsible for episodic ataxia 2, familial hemiplegic migraine type 1 (FHM1) and spinocerebellar ataxia type 6 (SCA6).
Toxin found in the venom of the funnel web spider, Agelenopsis aptera. Potent, selective blocker of mammalian P-type voltage-dependent calcium channels.
Features and Benefits
This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable