跳转至内容
Merck
CN

A6730

Sigma-Aldrich

Akt1/2激酶抑制剂

≥98% (HPLC), Akt1/2 kinase inhibitor, powder

别名:

1,3-二氢-1-（1-（（4-（6-苯基-1H-咪唑[4,5-g）喹喔啉-7-基）苯基）甲基）-4-哌啶基）-2H-苯并咪唑-2-酮 三氟乙酸盐 水合物, Akti-1/2 三氟乙酸盐 水合物, Akt抑制剂八 三氟乙酸盐 水合物

登录查看公司和协议定价

关于此项目

经验公式（希尔记法）:
C34H29N7O · xC2HF3O2 · yH2O
CAS Number:
616871-83-1
分子量:
551.64 (anhydrous free base basis)
MDL编号:
MFCD08705407
UNSPSC代码:
12352200
PubChem化学物质编号:
24891133
NACRES:
NA.77

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

Product Name

Akt1/2激酶抑制剂, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

yellow

溶解性

DMSO: ≥10 mg/mL

创始人

Merck & Co., Inc., Kenilworth, NJ, U.S.

储存温度

2-8°C

SMILES字符串

[H]O[H].OC(=O)C(F)(F)F.O=C1Nc2ccccc2N1C3CCN(CC3)Cc4ccc(cc4)-c5nc6cc7nc[nH]c7cc6nc5-c8ccccc8

InChI

1S/C34H29N7O.C2HF3O2.H2O/c42-34-39-26-8-4-5-9-31(26)41(34)25-14-16-40(17-15-25)20-22-10-12-24(13-11-22)33-32(23-6-2-1-3-7-23)37-29-18-27-28(36-21-35-27)19-30(29)38-33;3-2(4,5)1(6)7;/h1-13,18-19,21,25H,14-17,20H2,(H,35,36)(H,39,42);(H,6,7);1H2

InChI key

CRRPFKCJZALCLQ-UHFFFAOYSA-N

相关类别

应用

Akt在细胞增殖、凋亡、血管生成和糖尿病的信号转导途径中发挥作用。Akt1和Akt2双激酶抑制剂能够使肿瘤细胞对某些凋亡刺激敏感，并抑制体内Akt磷酸化。造血细胞中Akt1激酶的活性及其受细胞体内外信号因子的调节表明，AKT1的激活涉及激酶从胞质溶胶到膜的胞内易位。

生化/生理作用

Akt1/2激酶抑制剂；同工酶对Akt1有选择性。
同工酶选择性Akt1/2激酶抑制剂。在体外激酶试验中，Akt1/2激酶抑制剂显示IC50 = 58 nM、210 nM和2.12 mM，分别针对Akt1、Akt2和Akt3，抑制作用似乎是多重同源（酸碱度）结构域依赖性的，Akt1/2激酶抑制剂对酸碱度结构域缺失的Akts或其他密切相关的AGC家族激酶、PKA、PKC和SGK没有抑制作用，即使浓度高达50 & # 956；M.

特点和优势

该化合物由Merck & Co., Inc.（美国新泽西州Kenilworth）开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。
这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000223096
0000223096
0000190470
0000190470
0000143305

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Denise Treue et al.
International journal of cancer, 144(3), 545-557 (2018-09-06)
Cancer precision medicine largely relies on knowledge about genetic aberrations in tumors and next-generation-sequencing studies have shown a high mutational complexity in many cancers. Although a large number of the observed mutations is believed to be not causally linked with
Subhash Ajmani et al.
Journal of molecular graphics & modelling, 28(7), 683-694 (2010-02-16)
Protein kinase B (PKB, also known as Akt) belongs to the AGC subfamily of the protein kinase superfamily. Akt1 has been reported as a central player in regulation of metabolism, cell survival, motility, transcription and cell-cycle progression, among the signalling
Shaomin Peng et al.
Experimental eye research, 151, 179-189 (2016-09-07)
Mutations of claudin-19 cause severe ocular deficits that are not easily reconciled with its role in regulating the outer blood retinal barrier. ARPE-19 is a widely used culture model of the retinal pigment epithelium (RPE). ARPE-19 is unique among epithelial
Brad Larson et al.
Assay and drug development technologies, 7(6), 573-584 (2010-01-12)
Kinases continue to be one of the most important targets in today's drug discovery efforts. Following the identification of lead compounds through screening efforts, it is important to profile these leads against other kinases within that family, as well as
Z Lu et al.
Cell death and differentiation, 21(8), 1275-1289 (2014-04-29)
The process of autophagy has been described in detail at the molecular level in normal cells, but less is known of its regulation in cancer cells. Aplasia Ras homolog member I (ARHI; DIRAS3) is an imprinted tumor suppressor gene that
查看所有相关文献

商品

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

Discover Bioactive Small Molecules for Kinase Phosphatase Biology

实验方案

PKB/Akt

We offer many products related to PKB/Akt for your research needs.

相关内容

Cancer Research Modeling and Profiling Tools

Discover cancer research resources with modeling and profiling tools for cell culture, genomics, biomarkers, and more to help maximize your cancer research.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持