A6779
高碘酸氧化腺苷 5′-三磷酸 钠盐
≥97%, bacterial (corynebacterium sp), powder
别名:
oATP, 腺苷 5′-三磷酸-2′,3′-二醛
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关于此项目
经验公式（希尔记法）:
C10H14N5O13P3
化学文摘社编号:
分子量:
505.17
MDL编号:
UNSPSC代码:
41106305
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.51
产品名称
高碘酸氧化腺苷 5′-三磷酸 钠盐, ≥97%
生物来源
bacterial (corynebacterium sp)
质量水平
方案
≥97%
表单
powder
储存温度
−20°C
SMILES字符串
[Na].Nc1ncnc2n(cnc12)[C@H](O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)C=O)C=O
InChI
1S/C10H14N5O13P3.Na.H/c11-9-8-10(13-4-12-9)15(5-14-8)7(2-17)26-6(1-16)3-25-30(21,22)28-31(23,24)27-29(18,19)20;;/h1-2,4-7H,3H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;/t6-,7+;;/m0../s1
InChI key
IHQATUPGVKMGLT-AUCRBCQYSA-N
相关类别
一般描述
腺苷-5′-三磷酸-2′，3′-二醛是二醛的一种衍生物。
应用
腺苷-5′-三磷酸，高碘酸氧化钠盐已被用于：
- 作为嘌呤能受体的拮抗剂（P2×7抑制P2×7通路）
- 作为通过Ca2+评估P2x7-R活性的非特异性激动剂
- 评估细胞内ATP水平升高的生理意义
- 评估Flcn缺陷细胞中用于破骨细胞生成的P2rx7表达升高的生理意义
生化/生理作用
腺苷-5′-三磷酸-2′，3′-二醛被认为是P2×7受体的一种抑制剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Searching Novel Therapeutic Targets for Scleroderma: P2X7-Receptor Is Up-regulated and Promotes a Fibrogenic Phenotype in Systemic Sclerosis Fibroblasts.
Daniela Gentile et al.
Frontiers in pharmacology, 8, 638-638 (2017-09-29)
William Foulsham et al.
Scientific reports, 9(1), 8617-8617 (2019-06-15)
Adenosine triphosphate (ATP) is released into the extracellular environment during transplantation, and acts via purinergic receptors to amplify the alloimmune response. Here, using a well-established murine model of allogeneic corneal transplantation, we investigated the immunomodulatory mechanisms of the purinergic receptor
Ursula Schenk et al.
Science signaling, 1(39), ra6-ra6 (2008-10-02)
T cell receptor (TCR) stimulation results in the influx of Ca(2+), which is buffered by mitochondria and promotes adenosine triphosphate (ATP) synthesis. We found that ATP released from activated T cells through pannexin-1 hemichannels activated purinergic P2X receptors (P2XRs) to
Liver X receptor beta activation induces pyroptosis of human and murine colon cancer cells
Derangere V, et al.
Cell Death and Differentiation, 21(12), 1914-1914 (2014)
Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation
Baba M, et al.
Journal of Bone and Mineral Research, 33(10), 1785-1798 (2018)
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