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A6933

Acetyl-Amyloid β-Protein Fragment 15-20 Amide

Name: Acetyl-Amyloid β-Protein Fragment 15-20 Amide
Brand: SIGMA

≥97% (HPLC), powder

别名:

Ac-QKLVFF-NH₂, amyloid blocker

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关于此项目

经验公式（希尔记法）:

C₄₂H₆₃N₉O₈

化学文摘社编号:

189064-06-0

分子量:

822.01

NACRES:

NA.32

PubChem Substance ID:

329770908

UNSPSC Code:

12352202

MDL number:

MFCD17215285

Form:

powder

Assay:

≥97% (HPLC)

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属性

Quality Level

200

assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P05067

storage temp.

−20°C

SMILES string

CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc2ccccc2)C(N)=O

InChI

1S/C42H63N9O8/c1-25(2)22-33(49-38(55)30(18-12-13-21-43)47-39(56)31(46-27(5)52)19-20-35(44)53)41(58)51-36(26(3)4)42(59)50-34(24-29-16-10-7-11-17-29)40(57)48-32(37(45)54)23-28-14-8-6-9-15-28/h6-11,14-17,25-26,30-34,36H,12-13,18-24,43H2,1-5H3,(H2,44,53)(H2,45,54)(H,46,52)(H,47,56)(H,48,57)(H,49,55)(H,50,59)(H,51,58)/t30-,31-,32-,33-,34-,36-/m0/s1

InChI key

DDXTVYDSGCHGAN-PITCCTKHSA-N

Gene Information

human ... APP(351)

说明

Biochem/physiol Actions

Amyloid plaques characteristic of the Alzheimer brain contain fibrils composed of amyloid beta aggregates. Short peptides containing the sequence KLVFF have been shown to bind specifically to the homologous region in Aβ and are used to prevent full length amyloid fibril formation.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

067H0822

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Arrest of beta-amyloid fibril formation by a pentapeptide ligand.

L O Tjernberg et al.

The Journal of biological chemistry, 271(15), 8545-8548 (1996-04-12)

Polymerization of amyloid beta-peptide (Abeta) into amyloid fibrils is a critical step in the pathogenesis of Alzheimer's disease. Here, we show that peptides incorporating a short Abeta fragment (KLVFF; Abeta16-20) can bind full-length Abeta and prevent its assembly into amyloid

Controlling amyloid beta-peptide fibril formation with protease-stable ligands.