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Merck
CN

A7015

Sigma-Aldrich

N-(2-芴基)乙酰胺

≥98% (HPLC)

别名:

2-AAF, 2-乙酰氨基芴, N-乙酰基-2-氨基芴

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关于此项目

经验公式（希尔记法）:
C15H13NO
化学文摘社编号:
53-96-3
分子量:
223.27
Beilstein:
2807677
EC 号:
200-188-6
MDL编号:
MFCD00001116
UNSPSC代码:
12352103
PubChem化学物质编号:
24891166
NACRES:
NA.25

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方案

≥98% (HPLC)

表单

powder

mp

192-196 °C (lit.)

SMILES字符串

CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1

InChI

1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)

InChI key

CZIHNRWJTSTCEX-UHFFFAOYSA-N

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应用

N-（2-氟烯基）乙酰胺（2-乙酰氨基芴，2-AAF）是一种用于在2-AAF/部分肝切除大鼠等动物模型中诱发肝癌的遗传毒性致癌物。2-AAF可用于研究肝癌发生的机制，并在其鉴定或定量过程中用作参考材料。

生化/生理作用

一种遗传毒性致癌物，用于诱发大鼠肝癌模型。当因肝脏中的细胞色素 CYP1A2 发生 N-羟基化时，2-AAF 与 DNA 形成加合物，在肝脏和膀胱中发生肿瘤。

象形图

Health hazardExclamation mark
GHS08,GHS07

警示用语：

Danger

危险声明

H302,H350

危险分类

Acute Tox. 4 Oral - Carc. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCD1839
SLBS9794
SLBT5494
SLBT5333
SLBS9801

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