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Merck
CN

A7015

N-(2-芴基)乙酰胺

≥98% (HPLC)

别名:

2-AAF, 2-乙酰氨基芴, N-乙酰基-2-氨基芴

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关于此项目

经验公式（希尔记法）:
C15H13NO
化学文摘社编号:
53-96-3
分子量:
223.27
UNSPSC Code:
12352103
NACRES:
NA.25
PubChem Substance ID:
24891166
EC Number:
200-188-6
Beilstein/REAXYS Number:
2807677
MDL number:
MFCD00001116

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产品名称

N-(2-芴基)乙酰胺, ≥98% (HPLC)

InChI key

CZIHNRWJTSTCEX-UHFFFAOYSA-N

InChI

1S/C15H13NO/c1-10(17)16-13-6-7-15-12(9-13)8-11-4-2-3-5-14(11)15/h2-7,9H,8H2,1H3,(H,16,17)

SMILES string

CC(=O)Nc1ccc-2c(Cc3ccccc-23)c1

assay

≥98% (HPLC)

form

powder

mp

192-196 °C (lit.)

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Application

N-（2-氟烯基）乙酰胺（2-乙酰氨基芴，2-AAF）是一种用于在2-AAF/部分肝切除大鼠等动物模型中诱发肝癌的遗传毒性致癌物。2-AAF可用于研究肝癌发生的机制，并在其鉴定或定量过程中用作参考材料。

Biochem/physiol Actions

一种遗传毒性致癌物，用于诱发大鼠肝癌模型。当因肝脏中的细胞色素 CYP1A2 发生 N-羟基化时，2-AAF 与 DNA 形成加合物，在肝脏和膀胱中发生肿瘤。

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

hcodes

H302,H350

Hazard Classifications

Acute Tox. 4 Oral - Carc. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCD1839
SLBS9794
SLBT5494
SLBT5333
SLBS9801

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Christopher A Traina et al.
Journal of the American Chemical Society, 133(32), 12600-12607 (2011-07-15)
Water-soluble conjugated polymers with controlled molecular weight characteristics, absence of ionic groups, high emission quantum yields, and end groups capable of selective reactions of wide scope are desirable for improving their performance in various applications and, in particular, fluorescent biosensor
Hong Mu et al.
Nucleic acids research, 40(19), 9675-9690 (2012-08-21)
Nucleotide excision repair (NER) efficiencies of DNA lesions can vary by orders of magnitude, for reasons that remain unclear. An example is the pair of N-(2'-deoxyguanosin-8-yl)-2-aminofluorene (dG-C8-AF) and N-(2'-deoxyguanosin-8-yl)-2-acetylaminofluorene (dG-C8-AAF) adducts that differ by a single acetyl group. The NER
Jung-Eun Yeo et al.
Chemical research in toxicology, 25(11), 2462-2468 (2012-10-24)
Nucleotide excision repair (NER) removes lesions caused by environmental mutagens or UV light from DNA. A hallmark of NER is the extraordinarily wide substrate specificity, raising the question of how one set of proteins is able to recognize structurally diverse
Sana Javaid Awan et al.
Cell biology international, 41(1), 51-61 (2016-11-03)
Hepatic oval cells are likely to be activated during advanced stage of liver fibrosis to reconstruct damaged hepatic tissue. However, their scarcity, difficulties in isolation, and in vitro expansion hampered their transplantation in fibrotic liver. This study was aimed to
Samrat Chakraborty et al.
Molecular therapy. Nucleic acids, 20, 34-49 (2020-03-09)
Site-specific delivery of chemotherapeutics specifically to neoplastic hepatocytes without affecting normal hepatocytes should be a focus for potential therapeutic management of hepatocellular carcinoma (HCC). The aptamer TLS 9a with phosphorothioate backbone modifications (L5) has not been explored so far for
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DNA Damage and Repair

DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

DNA损伤和修复

DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。

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