A7154
氧化高碘酸腺苷
≥93%, synthetic, Powder
别名:
抗氧化剂, 腺苷-2′，3′-二醛
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关于此项目
经验公式（希尔记法）:
C10H11N5O4
化学文摘社编号:
分子量:
265.23
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51
MDL number:
产品名称
氧化高碘酸腺苷, ≥93%
SMILES string
Nc1ncnc2n(cnc12)C(OC(CO)C=O)C=O
InChI key
ILMNSCQOSGKTNZ-UHFFFAOYSA-N
InChI
1S/C10H11N5O4/c11-9-8-10(13-4-12-9)15(5-14-8)7(3-18)19-6(1-16)2-17/h1,3-7,17H,2H2,(H2,11,12,13)
biological source
synthetic (organic)
assay
≥93%
form
powder
solubility
0.2 M HCl: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
Quality Level
Application
高碘酸氧化腺苷已用于：
- 作为人胚胎肾细胞(HEK)-293 T中的精氨酸甲基转移酶抑制剂
- 作为H4神经胶质瘤的甲基化酶抑制剂
- 作为小鼠胚胎成纤维细胞NIH3T3的S-腺苷甲硫氨酸(AdoMet)依赖性甲基转移酶的广谱抑制剂
Biochem/physiol Actions
腺苷高碘酸氧化物/高碘酸氧化腺苷(Adox)是一种蛋白精氨酸甲基转移酶(PRMT)抑制剂。它还可抑制S-腺苷同型半胱氨酸水解酶并诱导细胞凋亡。可抑制组蛋白甲基转移酶，从而抑制组蛋白甲基化。Adox还可激发内源性细胞毒性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type N95 (US)
Jessica A Sipkens et al.
Atherosclerosis, 221(1), 48-54 (2011-12-30)
We have previously shown that homocysteine (Hcy) induces phosphatidylserine (PS) exposure, apoptosis and necrosis in human endothelial cells. Since it has been suggested that S-adenosylhomocysteine (SAH) is the main causative factor in Hcy-induced pathogenesis of cardiovascular disease, we evaluate here
Malin Hultberg et al.
Clinical biochemistry, 39(2), 160-163 (2005-12-07)
The metabolism of homocysteine is influenced by several dietary factors, including folate, cobalamin and possibly also the intake of polyhydroxylated phenolic compounds (polyphenols), which were shown to increase plasma homocysteine (tHcy) concentration. In order to reveal the cause of the
Ivon J M van der Linden et al.
Birth defects research. Part A, Clinical and molecular teratology, 82(10), 676-683 (2008-10-22)
An impaired DNA methylation has been suggested to underlie the complex etiology of neural tube defects (NTDs). Previously, we have demonstrated that inhibition of methylation by periodate oxidized adenosine (Adox) results in a widening of the anterior neuropore (ANP) in
Rita Castro et al.
Journal of molecular medicine (Berlin, Germany), 83(10), 831-836 (2005-06-25)
Hyperhomocysteinemia is a risk factor for atherosclerosis and vascular disease; however, the mechanism underlying this association remains poorly understood. Increased levels of intracellular S-adenosylhomocysteine (AdoHcy), secondary to homocysteine-mediated reversal of the AdoHcy hydrolase reaction, have been associated with reduced DNA
Francois H T Duong et al.
Hepatology (Baltimore, Md.), 43(4), 796-806 (2006-03-25)
Hepatitis C virus (HCV) infection is an important cause of chronic liver disease. Standard therapy, pegylated interferon alpha (pegIFNalpha) combined with ribavirin, results in a sustained response rate in approximately half of patients. The cause of treatment failure in the
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