A7154
氧化高碘酸腺苷
≥93%, synthetic, Powder
别名:
抗氧化剂, 腺苷-2′，3′-二醛
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关于此项目
经验公式（希尔记法）:
C10H11N5O4
化学文摘社编号:
分子量:
265.23
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
产品名称
氧化高碘酸腺苷, ≥93%
生物来源
synthetic (organic)
质量水平
方案
≥93%
表单
powder
溶解性
0.2 M HCl: 50 mg/mL, clear, colorless to faintly yellow
储存温度
−20°C
SMILES字符串
Nc1ncnc2n(cnc12)C(OC(CO)C=O)C=O
InChI
1S/C10H11N5O4/c11-9-8-10(13-4-12-9)15(5-14-8)7(3-18)19-6(1-16)2-17/h1,3-7,17H,2H2,(H2,11,12,13)
InChI key
ILMNSCQOSGKTNZ-UHFFFAOYSA-N
应用
高碘酸氧化腺苷已用于：
- 作为人胚胎肾细胞(HEK)-293 T中的精氨酸甲基转移酶抑制剂
- 作为H4神经胶质瘤的甲基化酶抑制剂
- 作为小鼠胚胎成纤维细胞NIH3T3的S-腺苷甲硫氨酸(AdoMet)依赖性甲基转移酶的广谱抑制剂
生化/生理作用
腺苷高碘酸氧化物/高碘酸氧化腺苷(Adox)是一种蛋白精氨酸甲基转移酶(PRMT)抑制剂。它还可抑制S-腺苷同型半胱氨酸水解酶并诱导细胞凋亡。可抑制组蛋白甲基转移酶，从而抑制组蛋白甲基化。Adox还可激发内源性细胞毒性。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type N95 (US)
Jin-Ah Park et al.
Molecules and cells, 31(4), 343-349 (2011-03-02)
Interphasic chromatin condenses into the chromosomes in order to facilitate the correct segregation of genetic information. It has been previously reported that the phosphorylation and methylation of the N-terminal tail of histone H3 are responsible for chromosome condensation. In this
Ryan Heit et al.
Journal of cell science, 122(Pt 16), 2957-2968 (2009-07-30)
Trimethylation of lysine 9 on histone H3 (H3K9me3) is known both to be necessary for proper chromosome segregation and to increase in late G2. We investigated the role of late G2 methylation, specifically in mitotic progression, by inhibiting methylation for
Christian Schwerk et al.
Oncogene, 24(47), 7002-7011 (2005-07-12)
We have analysed the importance of proper substrate methylation by S-adenosylmethionine-dependent methyltransferases for cell survival and cell cycle progression. We show that treatment of cells with the methyltransferase inhibitor adenosine dialdehyde (AdOx) causes cell cycle arrest and death in different
Regulation of arginine methylation in endothelial cells: role in premature senescence and apoptosis.
Alla Polotskaia et al.
Cell cycle (Georgetown, Tex.), 6(20), 2524-2530 (2007-08-30)
With the recent characterization of enzymes responsible for protein arginine methylation and demonstration that catabolic products of arginine methylation, such as asymmetric dimethylarginine (ADMA), are among the most powerful mechanisms of atherogenesis, developing endothelial dysfunction and cardiovascular complications in a
Malin Hultberg et al.
Clinical biochemistry, 39(2), 160-163 (2005-12-07)
The metabolism of homocysteine is influenced by several dietary factors, including folate, cobalamin and possibly also the intake of polyhydroxylated phenolic compounds (polyphenols), which were shown to increase plasma homocysteine (tHcy) concentration. In order to reveal the cause of the
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