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A7410

Amiloride hydrochloride hydrate

Name: Amiloride hydrochloride hydrate
Brand: SIGMA

≥98% (HPLC), powder, T-type calcium channel blocker

别名:

N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate

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关于此项目

经验公式（希尔记法）:

C₆H₈ClN₇O · HCl · xH₂O

化学文摘社编号:

2016-88-8

分子量:

266.09 (anhydrous basis)

UNSPSC Code:

12352200

PubChem Substance ID:

24277817

NACRES:

NA.77

MDL number:

MFCD03703482

Assay:

≥98% (HPLC)

Form:

powder

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属性

产品名称

Amiloride hydrochloride hydrate, ≥98% (HPLC), powder

Quality Segment

200

assay

≥98% (HPLC)

form

powder

color

, White to Yellow and Faint Green to Green and Yellow-Green

mp

285-288 °C (dec.)

solubility

H₂O: 50 mg/mL, hazy (Very Faint Yellow to Dark Yellow and Very Faint Green-Yellow to Dark Green-Yellow and Very Faint Brown-Yellow to Dark Brown-Yellow)

originator

Perrigo

storage temp.

room temp

SMILES string

O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N

InChI

1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2

InChI key

WDZJJRLYFQNCQL-UHFFFAOYSA-N

Gene Information

说明

Application

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.

Biochem/physiol Actions

Selective T-type Ca²⁺ and epithelial sodium channel blocker

Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Disclaimer

Protect from light.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P264 - P270 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c