Name: Amiloride hydrochloride hydrate
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₆H₈ClN₇O · HCl · xH₂O

CAS Number:

2016-88-8

分子量:

266.09 (anhydrous basis)

MDL编号:

MFCD03703482

UNSPSC代码:

12352200

PubChem化学物质编号:

24277817

NACRES:

NA.77

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Product Name

Amiloride hydrochloride hydrate, ≥98% (HPLC), powder

质量水平

200

方案

≥98% (HPLC)

表单

powder

颜色

yellow

mp

285-288 °C (dec.)

溶解性

H₂O: 50 mg/mL, clear, yellow-green

创始人

Perrigo

储存温度

room temp

SMILES字符串

O.Cl.NC(=N)NC(=O)c1nc(Cl)c(N)nc1N

InChI

1S/C6H8ClN7O.ClH.H2O/c7-2-4(9)13-3(8)1(12-2)5(15)14-6(10)11;;/h(H4,8,9,13)(H4,10,11,14,15);1H;1H2

InChI key

WDZJJRLYFQNCQL-UHFFFAOYSA-N

基因信息

应用

Amiloride is a selective T-type calcium channel blocker, an epithelial sodium channel blocker and a selective inhibitor of urokinase plasminogen activator (uPA). Amiloride has been used in a study to develop an alternative treatment for constipation.

生化/生理作用

Selective T-type Ca²⁺ and epithelial sodium channel blocker

Selective T-type calcium channel blocker and blocker of epithelial sodium channel. Selective inhibitor of urokinase plasminogen activator (uPA).

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) and Imidazoline Binding Sites pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Perrigo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.