生物来源
rabbit
质量水平
偶联物
agarose conjugate
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human
分析物化学类别
proteins (c-Myc)
技术
affinity chromatography: suitable
immunoprecipitation (IP): suitable
容量
≥10 nmol/mL binding capacity (c-Myc tagged fusion protein)
≥7 nmol/mL elution capacity (c-Myc tagged fusion protein)
UniProt登记号
储存温度
2-8°C
基因信息
human ... MYC(4609)
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一般描述
人c-Myc原癌基因属于MYC癌基因家族，是在几种致白血病逆转录病毒中发现的禽v-Myc基因的人细胞同源物。c-Myc基因位于人类染色体8q24.21。其两个主结构域包括具有螺旋-环-螺旋/亮氨酸-拉链基序的N末端盒区域和C末端基本区域
免疫原
人p62c-Myc蛋白的合成肽。
应用
兔源抗c-Myc琼脂糖亲和凝胶抗体已用于：
- 染色质免疫沉淀 (ChIP)
- 免疫共沉淀
- 蛋白质印迹
- 免疫荧光
- 免疫沉淀
生化/生理作用
抗c-Myc可识别位于c-Myc标记融合蛋白上的表位。
许多人类肿瘤中观察到c-Myc原癌基因表达增加。在血管肉瘤中观察到Myc基因位点扩增，在伯基特氏淋巴瘤中Myc基因位点出现易位。c-Myc是主要的调控基因，可靶向多种代谢事件。位于人c-Myc氨基酸残基410-419（EQKLISEEDL）内的表位已在许多表达载体中广泛用作标签，使蛋白质能够作为c-Myc标记融合蛋白进行表达。抗c-Myc琼脂糖可用于纯化细菌裂解液或转染细胞中表达的c-Myc标记融合蛋白。
外形
悬浮的琼脂糖颗粒(1：1，v/v)溶于0.01 M磷酸盐缓冲液中，含有15mM叠氮化钠。
制备说明
为持续使用并延长存储时间，请2°C至8°C存储。请勿冷冻。
其他说明
免责声明
除非我们的产品目录另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Riko Hatakeyama et al.
Molecular and cellular biology, 30(24), 5598-5607 (2010-10-20)
Endocytosis of nutrient transporters is stimulated under various conditions, such as elevated nutrient availability. In Saccharomyces cerevisiae, endocytosis is triggered by ubiquitination of transporters catalyzed by the E3 ubiquitin ligase Rsp5. However, how the ubiquitination is accelerated under certain conditions
Wei Wei et al.
Journal of virology, 88(1), 583-591 (2013-11-01)
Sterile alpha motif and HD domain-containing protein 1 (SAMHD1) restricts human immunodeficiency virus type 1 (HIV-1) infection in myeloid cells but is inactivated by certain classes of simian immunodeficiency virus (SIV) Vpx proteins. Vpx proteins recruit the DCAF1-CRL4 E3 ubiquitin
Zhong-Lin Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(5), 2160-2165 (2011-01-20)
The diterpenoid phytohormone gibberellin (GA) controls diverse developmental processes throughout the plant life cycle. DELLA proteins are master growth repressors that function immediately downstream of the GA receptor to inhibit GA signaling. By doing so, DELLAs also play pivotal roles
Sachiko Takikawa et al.
Epigenetics, 8(12), 1268-1279 (2013-10-19)
Genomic imprinting is a common epigenetic phenomenon in mammals. Dysregulation of genomic imprinting has been implicated in a variety of human diseases. ZFP57 is a master regulator in genomic imprinting. Loss of ZFP57 causes loss of DNA methylation imprint at
Peter Wehner et al.
Development (Cambridge, England), 138(7), 1321-1327 (2011-02-26)
RACK1 is an evolutionarily conserved intracellular adaptor protein that is involved in a wide range of processes including cell adhesion and migration; however, its role in vertebrate development is largely unknown. Here, we identify RACK1 as a novel interaction partner
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