A7606
Aprindine 盐酸盐
≥98% (HPLC), solid
别名:
N-(2,3-Dihydro-1H-inden-2-yl)-N′,N′-diethyl-N-phenyl-1,3-propanediamine hydrochloride, Amidonal
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关于此项目
经验公式（希尔记法）:
C22H30N2 · HCl
化学文摘社编号:
分子量:
358.95
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
251-418-7
MDL number:
产品名称
Aprindine 盐酸盐, ≥98% (HPLC), solid
InChI
1S/C22H30N2.ClH/c1-3-23(4-2)15-10-16-24(21-13-6-5-7-14-21)22-17-19-11-8-9-12-20(19)18-22;/h5-9,11-14,22H,3-4,10,15-18H2,1-2H3;1H
InChI key
KIPFVRHNAAZJOD-UHFFFAOYSA-N
SMILES string
Cl.CCN(CC)CCCN(C1Cc2ccccc2C1)c3ccccc3
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
H2O: >10 mg/mL
storage temp.
2-8°C
Quality Level
Application
Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine hydrochloride also inhibits the activities of calmodulin-sitmulated cyclic 3′:5′-nucleotide phosphodiesterase and Ca-ATPase.
Biochem/physiol Actions
Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker.
Aprindine hydrochloride is a class Ib antiarrhythmic and hERG channel blocker. Aprindine shows structure similarities to lidocaine and procainamide and is effective in treatment of patients with ventricular premature depolarizations, ventricular tachycardia, and supraventricular arrhythmias. Aprindine inhibits the activation of bovine brain cyclic 3′:5′-nucleotide phosphodiesterase (EC 3.1.4.17) by calmodulin and inhibits calmodulin-stimulated Ca-ATPase (ATP phosphohydrolase EC 3.6.1.3) activity.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
S Kasahara et al.
Kokyu to junkan. Respiration & circulation, 37(11), 1225-1230 (1989-11-01)
Aprindine hydrochloride (aprindine) was administered orally in 17 Japanese patients with supraventricular or ventricular tachyarrhythmias, and the clinical effects and plasma concentration levels were evaluated. The antiarrhythmic effects were defined using Holter ECG recordings. Aprindine was administered orally with a
Luisa Ibáñez et al.
Archives of internal medicine, 165(8), 869-874 (2005-04-27)
Since the publication of a major international case-control study on the risk of agranulocytosis associated with the use of medicines in the 1980s, many new drugs have been introduced in therapeutics. Seventeen units of hematology contribute to the case-control surveillance
H Yoshida et al.
Journal of cardiovascular electrophysiology, 10(9), 1262-1270 (1999-10-12)
A new strategy to elucidate the molecular mechanisms underlying the long QT syndrome (LQTS) is now available with genetic mutational analyses and characterization of ion channel mutations. In a 26-year-old woman with LQTS, we identified a novel missense mutation in
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