A7687
芦荟大黄素
≥95% (HPLC)
别名:
1,8-二羟基-3-（羟甲基）蒽甲苯, 1,8-二羟基3-羟甲基蒽甲苯, 3-羟甲基白杨嗪, 弹力素
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经验公式（希尔记法）:
C15H10O5
化学文摘社编号:
分子量:
270.24
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
EC Number:
207-571-7
Beilstein/REAXYS Number:
2059062
MDL number:
产品名称
芦荟大黄素, ≥95% (HPLC)
InChI key
YDQWDHRMZQUTBA-UHFFFAOYSA-N
InChI
1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
SMILES string
OCc1cc(O)c2C(=O)c3c(O)cccc3C(=O)c2c1
biological source
plant root (Rheum palmatum)
assay
≥95% (HPLC)
form
powder
technique(s)
HPLC: suitable
color
yellow to brown
storage temp.
2-8°C
Quality Level
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Application
芦荟大黄素已被用作标准品，用于通过高效液相色谱 (HPLC) 分离和鉴定木立芦荟（Aloe arborescens Miller var. natalensis Berger）中的酚类化合物。
Biochem/physiol Actions
复方泻药/泻药；通过释放内源性乙酰胆碱来增加肠道平滑肌的收缩。抗肿瘤活性与活性氧簇 (ROS) 产生增加相关，活性氧簇反过来降低线粒体跨膜电位，从而诱导渗透性转换，启动一系列事件，最终导致细胞凋亡。遗传毒性和致突变性似乎是由于芦荟大黄素抑制了拓扑异构酶II的活性。
芦荟大黄素具有抗菌、抗病毒、消炎和保肝作用。
General description
芦荟大黄素是在芦荟中天然存在的一种羟基蒽醌。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages
Park MY, et al.
Bioscience, Biotechnology, and Biochemistry, 73(4), 828-832 (2009)
Radical-scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats
Beppu H, et al.
Journal of Ethnopharmacology, 89(1), 37-45 (2003)
Mildred Acevedo-Duncan et al.
International immunopharmacology, 4(14), 1775-1784 (2004-11-09)
Aloe-emodin (1,8-dihydroy-3-[hydroxymethyl]-anthraquione) purified from Aloe vera leaves has been reported to have antitumor activity. The objectives of our research were to determine how aloe-emodin regulates the cell cycle, cell proliferation and protein kinase C (PKC) during glioma growth and development.
Jun-ming Guo et al.
Acta pharmacologica Sinica, 28(12), 1991-1995 (2007-11-23)
The aim of this study was to investigate the effects of aloe-emodin, a natural compound from the root and rhizome of Rheum palmatum, on the growth of human cervical cancer cells, HeLa. HeLa cells were treated with various concentrations of
Yiqun Du et al.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 24(2), 746-753 (2019-05-28)
To study the anticancer effects of aloe emodin against the MIAPaCa-2 and PANC-1 human pancreatic adenocarcinoma cancer cell lines by evaluating its effect on autophagic cell death, mitochondrial membrane potential (ΛΨm) loss and cell cycle arrest. The MTT assay was
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