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A7699

腺苷 5′-三磷酸二钠盐水合物

Name: 腺苷 5′-三磷酸 二钠盐 水合物
Brand: SIGMA

BioXtra, ≥99% (HPLC), from microbial

别名:

ATP 二钠盐

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经验公式（希尔记法）:

C₁₀H₁₄N₅Na₂O₁₃P₃ · xH₂O

化学文摘社编号:

34369-07-8

分子量:

551.14 (anhydrous basis)

PubChem Substance ID:

24891270

eCl@ss:

32160414

UNSPSC Code:

41106305

NACRES:

NA.51

EC Number:

213-579-1

MDL number:

MFCD00150755

Form:

powder

Assay:

≥99% (HPLC)

Solubility:

H₂O: 50 mg/mL, clear, colorless

Biological source:

microbial

Color:

white

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biological source

microbial

Quality Level

300

product line

BioXtra

assay

≥99% (HPLC)

form

powder

mol wt

551.14 g/mol

impurities

≤0.1% inorganic P, ≤3% solvent content

color

white

pKa

(1) 4.0, (2) 6.5

solubility

H₂O: 50 mg/mL, clear, colorless

anion traces

chloride (Cl^-): ≤0.05%

cation traces

Al: ≤0.005%, Ca: ≤0.01%, Cu: ≤0.001%, Fe: ≤0.05%, K: ≤0.01%, Mg: ≤0.005%, NH₄⁺: ≤0.05%, Pb: ≤0.001%, Zn: ≤0.0005%

λ_max

259 nm

fluorescence

λ_em 15.4 in 0.1 M phosphate pH 7.0

storage temp.

−20°C

SMILES string

O.[Na+].[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O

InChI

1S/C10H16N5O13P3.2Na.H2O/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20;;;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20);;;1H2/q;2*+1;/p-2/t4-,6-,7-,10-;;;/m1.../s1

InChI key

NTBQNWBHIXNPRU-MSQVLRTGSA-L

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Application

腺苷5γ-三磷酸腺苷(ATP)是体内能量储存和代谢的中心成分。 ATP应用于许多细胞过程、呼吸、生物合成反应、运动和细胞分裂。ATP是许多激酶的底物，这些激酶参与细胞信号和腺苷酸环化酶(s)，产生第二个信使 cAMP。 ATP提供代谢能量来驱动代谢泵。 ATP在一系列酶促反应中充当辅酶。

Biochem/physiol Actions

P₂ 嘌呤受体激动剂。

P₂ 嘌呤能激动剂；增加 Ca²⁺-激活的 K⁺ 通道的活性；ATP-依赖酶系统的底物

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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Local release of ATP into the arterial inflow and venous drainage of human skeletal muscle: insight from ATP determination with the intravascular microdialysis technique.

Stefan P Mortensen et al.

The Journal of physiology, 589(Pt 7), 1847-1857 (2011-02-09)

Intraluminal ATP could play an important role in the local regulation of skeletal muscle blood flow, but the stimuli that cause ATP release and the levels of plasma ATP in vessels supplying and draining human skeletal muscle remain unclear. To

Adenine nucleotide control of coronary blood flow during exercise.

Mark W Gorman et al.

American journal of physiology. Heart and circulatory physiology, 299(6), H1981-H1989 (2010-09-21)

The adenine nucleotide hypothesis postulates that the ATP released from red blood cells is broken down to ADP and AMP in coronary capillaries and that ATP, ADP, and AMP act on purinergic receptors on the surface of capillary endothelial cells.

MARK4 (Microtubule Affinity-Regulating Kinase 4)-Dependent Inflammasome Activation Promotes Atherosclerosis-Brief Report.

Marc Clement et al.

Arteriosclerosis, thrombosis, and vascular biology, 39(8), 1645-1651 (2019-06-07)

MARK4 (microtubule affinity-regulating kinase 4) regulates NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3) inflammasome activation. The aim of the study is to examine the role of MARK4 in hematopoietic cells during atherosclerosis. We show increased MARK4

Oncogenic KrasG12D causes myeloproliferation via NLRP3 inflammasome activation.

Shaima'a Hamarsheh et al.

Nature communications, 11(1), 1659-1659 (2020-04-05)

Oncogenic Ras mutations occur in various leukemias. It was unclear if, besides the direct transforming effect via constant RAS/MEK/ERK signaling, an inflammation-related effect of KRAS contributes to the disease. Here, we identify a functional link between oncogenic KrasG12D and NLRP3

Dielectric spectra broadening as a signature for dipole-matrix interaction. III. Water in adenosine monophosphate/adenosine-5'-triphosphate solutions.

Alexander Puzenko et al.

The Journal of chemical physics, 137(19), 194502-194502 (2012-11-28)

In this, the third part of our series on the dielectric spectrum symmetrical broadening of water, we consider the nucleotide aqueous solutions. Where in Parts I [E. Levy et al., J. Chem. Phys. 136, 114502 (2012)] and II [E. Levy

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全球贸易项目编号

货号	GTIN
A7699-5G	04061835511754
A7699-1G	04061835571000
A7699-10G	04061833386163

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