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Merck
CN

A8003

Sigma-Aldrich

别嘌醇

synthetic (organic), ≥99% (TLC), xanthine oxidase inhibitor, powder

别名:

1H-吡唑并 (3,4-d) 嘧啶-4-醇, 4-羟基吡唑并 (3,4-d) 嘧啶, 4-羟基吡唑并 [3,4-d] 嘧啶, HPP

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关于此项目

经验公式（希尔记法）:
C5H4N4O
化学文摘社编号:
315-30-0
分子量:
136.11
EC 号:
206-250-9
MDL编号:
MFCD00599413
UNSPSC代码:
12352202
PubChem化学物质编号:
24278141
NACRES:
NA.77

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产品名称

别嘌醇, xanthine oxidase inhibitor

生物来源

synthetic (organic)

质量水平

200

方案

≥99% (TLC)

表单

powder

mp

>300 °C (lit.)

溶解性

1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

储存温度

room temp

SMILES字符串

O=C1NC=Nc2[nH]ncc12

InChI

1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)

InChI key

OFCNXPDARWKPPY-UHFFFAOYSA-N

基因信息

human ... XDH(7498)

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相关类别

应用

别嘌呤醇已用于：
  • 降低尿酸浓度，研究其对小鼠肾损伤和炎症的疗效
  • 作为黄嘌呤氧化酶抑制剂，检测杀白细胞素(PVL)中性粒细胞胞外诱捕网(NETosis)对人多形核细胞(hPMN)不同酶、通道或细胞器的依赖性
  • 作为参考标准品，体外研究橄榄叶组分对黄嘌呤氧化酶的抑制作用

别嘌呤醇适合：
  • 静脉注射小鼠抑制黄嘌呤氧化酶
  • 用作黄嘌呤氧化酶抑制剂
  • 用作黄嘌呤氧化酶抑制试验的阳性对照
  • 制备威斯康星大学保存液，用于在猪胰岛纯化中保持渗透压稳定，增强胰岛和胰腺泡片段的密度差异

生化/生理作用

别嘌呤醇是一种嘌呤类似物，可抑制某些参与嘌呤代谢的酶。减少体内的尿酸合成。别嘌呤醇可抑制黄嘌呤氧化酶，对动脉粥样硬化、急性肺损伤和充血性心力衰竭具有抗炎作用。
黄嘌呤氧化酶和初始嘧啶生物合成的抑制剂。治疗高尿酸血症和痛风的经典药物。

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H301,H317

危险分类

Acute Tox. 3 Oral - Skin Sens. 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX5681
MKCV7617
MKCW5113
MKCV0752
MKCS5502

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