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Merck
CN

A8003

别嘌醇

synthetic (organic), ≥99% (TLC), xanthine oxidase inhibitor, powder

别名:

1H-吡唑并 (3,4-d) 嘧啶-4-醇, 4-羟基吡唑并 (3,4-d) 嘧啶, 4-羟基吡唑并 [3,4-d] 嘧啶, HPP

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关于此项目

经验公式（希尔记法）:
C5H4N4O
化学文摘社编号:
315-30-0
分子量:
136.11
NACRES:
NA.77
PubChem Substance ID:
24278141
UNSPSC Code:
12352202
EC Number:
206-250-9
MDL number:
MFCD00599413

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产品名称

别嘌醇, xanthine oxidase inhibitor

InChI key

OFCNXPDARWKPPY-UHFFFAOYSA-N

InChI

1S/C5H4N4O/c10-5-3-1-8-9-4(3)6-2-7-5/h1-2H,(H2,6,7,8,9,10)

SMILES string

O=C1NC=Nc2[nH]ncc12

biological source

synthetic (organic)

assay

≥99% (TLC)

form

powder

mp

>300 °C (lit.)

solubility

1 M NaOH: soluble 50 mg/mL, clear to very slightly hazy, colorless to faintly yellow

storage temp.

room temp

Quality Level

200

Gene Information

human ... XDH(7498)

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相关类别

Application

别嘌呤醇已用于：
  • 降低尿酸浓度，研究其对小鼠肾损伤和炎症的疗效
  • 作为黄嘌呤氧化酶抑制剂，检测杀白细胞素(PVL)中性粒细胞胞外诱捕网(NETosis)对人多形核细胞(hPMN)不同酶、通道或细胞器的依赖性
  • 作为参考标准品，体外研究橄榄叶组分对黄嘌呤氧化酶的抑制作用

别嘌呤醇适合：
  • 静脉注射小鼠抑制黄嘌呤氧化酶
  • 用作黄嘌呤氧化酶抑制剂
  • 用作黄嘌呤氧化酶抑制试验的阳性对照
  • 制备威斯康星大学保存液，用于在猪胰岛纯化中保持渗透压稳定，增强胰岛和胰腺泡片段的密度差异

Biochem/physiol Actions

别嘌呤醇是一种嘌呤类似物，可抑制某些参与嘌呤代谢的酶。减少体内的尿酸合成。别嘌呤醇可抑制黄嘌呤氧化酶，对动脉粥样硬化、急性肺损伤和充血性心力衰竭具有抗炎作用。
黄嘌呤氧化酶和初始嘧啶生物合成的抑制剂。治疗高尿酸血症和痛风的经典药物。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301,H317

Hazard Classifications

Acute Tox. 3 Oral - Skin Sens. 1

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCX5681
MKCV7617
MKCW5113
MKCV0752
MKCS5502

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The Kobe journal of medical sciences, 64(3), E107-E114 (2019-01-23)
Hyperuricemia contributed to endothelial dysfunction, activation of the RAS system, increased oxidative stress and maladaptive immune system response. M1 and M2 macrophages were known to contribute to the onset of renal fibrosis. This study aimed to look at the effect
H Kubo et al.
The Journal of clinical investigation, 97(11), 2680-2684 (1996-06-01)
Mice with chronic granulomatous disease (X-CGD mice) generated by mutating the X-linked gene for a subunit of NADPH oxidase have been analyzed for their ability to respond to intravenous injection of purified cobra venom factor (CVF). This agent in wild-type
Nitrate partially inhibits lipopolysaccharide-induced inflammation by maintaining mitochondrial function.
Yang Yang et al.
The Journal of international medical research, 48(2), 300060520902605-300060520902605 (2020-02-12)
J Flemmig et al.
Phytomedicine : international journal of phytotherapy and phytopharmacology, 18(7), 561-566 (2010-12-15)
In Mediterranean folk medicine Olea europaea L. leaf (Ph.Eur.) preparations are used as a common remedy for gout. In this in vitro study kinetic measurements were performed on both an 80% ethanolic (v/v) Olea europaea leaf dry extract (OLE) as
Michael P M van der Burg et al.
TheScientificWorldJournal, 3, 1154-1159 (2003-12-04)
Generally, prior to the purification of isolated pancreatic islets, the collagenase-digested tissue is incubated in the University of Wisconsin solution (UWS; approximately 320 mOsm) for osmotic stabilization to preserve or improve the density differences between islets and acinar fragments. The
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Discover critical characteristics to consider when working with enzyme inhibitors, such as cell permeability, the prozone effect, and Lipinski’s rule of 5.

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