A8016
5′-[β-硫代]二磷酸腺苷 三锂盐
≥80% (HPLC), P2Y receptor agonist., powder
别名:
ADP-β-S, Ado-5′-PP[S], 腺苷-5′-0-（2-硫代二磷酸） 三锂盐
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关于此项目
经验公式（希尔记法）:
C10H12Li3N5O9P2S
化学文摘社编号:
分子量:
461.07
UNSPSC Code:
41106305
eCl@ss:
32160414
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
5′-[β-硫代]二磷酸腺苷 三锂盐, ≥80% (HPLC)
SMILES string
[Li+].[Li+].[Li+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](COP([O-])(=O)OP([O-])([O-])=S)[C@@H](O)[C@H]3O
InChI
1S/C10H15N5O9P2S.3Li/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(23-10)1-22-25(18,19)24-26(20,21)27;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H2,11,12,13)(H2,20,21,27);;;/q;3*+1/p-3/t4-,6-,7-,10-;;;/m1.../s1
InChI key
CPKFUAYUUSSFFZ-MSQVLRTGSA-K
assay
≥80% (HPLC)
form
powder
storage temp.
−20°C
Quality Level
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Application
5′-[β-硫代]二磷酸腺苷是AMP依赖性酶系统的底物和抑制剂。 5′-[β-硫代]二磷酸腺苷已被用于探索人食管运动的肌间控制机制以及硝化和非硝化神经递质的效应。
用5′-[β-硫代]二磷酸腺苷三锂盐诱发大鼠神经性疼痛，研究了背角大麻素CB2受体激活对P2Y12和P2Y13（嘌呤受体）受体表达的效应。
Biochem/physiol Actions
P2Y 受体激动剂。
Features and Benefits
该化合物的相关信息整理于受体分类和信号转导手册的 P2受体：P2Y G蛋白家族 页面。想要浏览手册的其他页面， 请单击此处。
General description
AMP依赖性酶系统的底物和抑制剂。
Other Notes
不可水解ADP类似物
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - STOT SE 2
target_organs
Eyes,Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
B Lecea et al.
American journal of physiology. Gastrointestinal and liver physiology, 300(5), G782-G794 (2011-02-19)
The aim of this study was to explore the myenteric mechanisms of control of human esophageal motility and the effect of nitrergic and nonnitrergic neurotransmitters. Human circular esophageal strips were studied in organ baths and with microelectrodes. Responses following electrical
Activation of dorsal horn cannabinoid CB2 receptor suppresses the expression of P2Y 12 and P2Y 13 receptors in neuropathic pain rats
Niu J, et al.
Journal of Neuroinflammation, 14(1), 185-185 (2017)
Alexander K Filippov et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 26(36), 9340-9348 (2006-09-08)
We have shown previously that stimulation of heterologously expressed P2Y1 nucleotide receptors inhibits M-type K+ currents in sympathetic neurons. We now report that activation of endogenous P2Y1 receptors induces inhibition of the M-current in rat CA1/CA3 hippocampal pyramidal cells in
Tibor Kiss
The European journal of neuroscience, 21(8), 2177-2185 (2005-05-05)
Members of the mytilus inhibitory peptide (MIP) family play an important role in the modulation of many physiological processes in molluscs. The signal transduction pathways affected by the MIP effect have not, however, been elucidated. Application of guanosine 5'-[gamma-thio]triphosphate tetralithium
Goody, R. S., and Eckstein, F.
Journal of the American Chemical Society, 93, 6252-6252 (1971)
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