A8264
4-氨基邻苯二甲酰肼
≥98% (HPLC), powder
别名:
6-氨基-2,3-二氢-1,4-酞嗪二酮, 异鲁米诺
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关于此项目
经验公式（希尔记法）:
C8H7N3O2
化学文摘社编号:
分子量:
177.16
Beilstein:
164804
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.83
产品名称
4-氨基邻苯二甲酰肼,
方案
≥98% (HPLC)
表单
powder
mp
300 °C (lit.)
溶解性
2 M NH4OH: 50 mg/mL, clear to slightly hazy
SMILES字符串
Nc1ccc2C(=O)NNC(=O)c2c1
InChI
1S/C8H7N3O2/c9-4-1-2-5-6(3-4)8(13)11-10-7(5)12/h1-3H,9H2,(H,10,12)(H,11,13)
InChI key
HUDPLKWXRLNSPC-UHFFFAOYSA-N
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应用
4-氨基邻苯二甲酰肼（异鲁米诺）已用于：
- 假结核耶氏菌感染后骨髓(BM)中性粒细胞的化学发光法活性氧(ROS)检测
- 克雷伯氏肺炎菌(K. pneumonia)暴露后中性粒细胞的活性氧检测
- 甲酰-蛋氨酸-亮氨酸-脯氨酸刺激后中性粒细胞的活性氧检测
生化/生理作用
4-氨基邻苯二甲酰肼或异鲁米诺是由酞嗪环构成的化学发光试剂，亲水性更高于鲁米诺。异鲁米诺在商业上广泛用于各种体外免疫分析，是可用于研究活性氧的放大性化学发光试剂。异鲁米诺也可用作电发光生物传感器(ECL)和微生物快速检测探针。
特点和优势
能发出化学荧光。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
B G Yushkov et al.
Bulletin of experimental biology and medicine, 150(3), 352-354 (2011-01-18)
The effects of 3-aminophthalhydrazide and carrageenan on reparative regeneration and expression of CD117 by liver cells after partial hepatectomy were studied in mice. 3-Aminophthalhydrazide stimulated regeneration of the liver and increased the count of CD117(+) hepatocytes. By contrast, carrageenan inhibited
Viera Jancinová et al.
Redox report : communications in free radical research, 11(3), 110-116 (2006-06-30)
To address the question why isoluminol, but not luminol, failed to detect oxidants produced intracellularly, differences between these luminophores were investigated with respect to physicochemical parameters and the character of chemiluminescence signal. Our results showed the isoluminol molecule to be
Kazuhiko Tsukagoshi et al.
Journal of chromatography. A, 1143(1-2), 288-290 (2007-02-03)
In our previous study, we developed capillary electrophoresis with an ultraviolet absorption/chemiluminescence dual detection system. Here, to demonstrate one of the possible applications of the capable system as well as confirm the advantage, migration behavior of isoluminol isothiocyanate-labeled alpha-amino acids
Caifeng Ding et al.
Chemical communications (Cambridge, England), 46(42), 7990-7992 (2010-09-25)
A new strategy of photoelectrochemical (PEC) analysis with chemiluminescence (CL) of the isoluminol-H(2)O(2)-Co(2+) system as a light source for the determination of physiological thiols in cancer cells was reported for the first time.
M T Abidov et al.
Bulletin of experimental biology and medicine, 153(1), 61-63 (2012-07-19)
The content of CD117(+)cells in the kidneys and CD45(low)CD117(+)cells in the bone marrow and blood of mice were studied after partial nephrectomy and under conditions of macrophage stimulation with 3-aminophthalhydrazide. The counts of tubular CD117(+)epitheliocytes sharply increased and the content
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