A8376
酰基酶Ⅰ 来源于猪肾脏
Grade II, salt-free, lyophilized powder, 300-1,500 units/mg protein
别名:
N-酰基氨基酸酰胺水解酶, 氨基酰化酶
类型
Grade II
质量水平
表单
salt-free, lyophilized powder
比活
300-1,500 units/mg protein
UniProt登记号
储存温度
−20°C
基因信息
pig ... ACY1(396930)
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应用
猪肾中的酰化酶I已被用于研究各种S-烷基-N-乙酰基-L-半胱氨酸及其碳、氧类似物的酰化酶I催化的脱乙酰作用。 酰化酶I可能有助于催化N-乙酰氨基酸生成对映体纯的 L-氨基酸。
生化/生理作用
酰化酶I是一种锌金属蛋白，可催化非天然和很少发生的α氨基酸的动力学分解。它对N-酰基L-α-氨基酸水解的对映选择性几乎是绝对的，但它接受具有广泛结构和功能性的底物。酰化酶I催化N-乙酰基-L-半胱氨酸和S-烷基-N-乙酰基-L-半胱氨酸的脱乙酰化。正丁基丙二酸是酰化酶I的抑制剂。S-烷基-N-乙酰基-L-半胱氨酸与短(C0-C3)和不分枝S-烷基取代已被发现是良好的酰化酶I底物。
分析说明
通过缩二脲法测定的蛋白质。
其他说明
一个单元将在pH 7.0和25℃条件下每小时水解1.0 μmole N-乙酰-L-蛋氨酸。
警示用语：
Danger
危险分类
Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
动植物源性产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kinetic resolution of unnatural and rarely occurring amino acids: enantioselective hydrolysis of N-acyl amino acids catalyzed by acylase I
Chenault HK, et al.
Journal of the American Chemical Society, 111(16), 6354-6364 (1989)
V Uttamsingh et al.
Chemical research in toxicology, 11(7), 800-809 (1998-07-22)
The aminoacylase that catalyzes the hydrolysis of N-acetyl-L-cysteine (NAC) was identified as acylase I after purification by column chromatography and electrophoretic analysis. Rat kidney cytosol was fractionated by ammonium sulfate precipitation, and the proteins were separated by ion-exchange column chromatography
A S Bommarius et al.
Annals of the New York Academy of Sciences, 672, 126-136 (1992-11-30)
The method of measuring enzyme deactivation by monitoring necessary addition of fresh enzyme to keep a constant degree of conversion in a CSTR at constant [E] x tau, the product of concentration of active enzyme [E] and residence time tau
Albert P Chen et al.
NMR in biomedicine, 24(5), 514-520 (2011-06-16)
Reporter-based cell detection and localization in vivo may become an important imaging tool with the emergence of cellular therapy. With the strong signal enhancement provided by dynamic nuclear polarization, an NMR-based reporter probe system utilizing specific enzyme expression and activity
Keya Cai et al.
Sheng wu gong cheng xue bao = Chinese journal of biotechnology, 24(2), 285-290 (2008-05-10)
Three model silkworms, highly resistant strain, highly susceptible strain and their near isogenic line were established by hybridization and backcross. The resistance of silkworm (Bombyx mori L.) to BmNPV was studied at proteomic level using two-dimensional gel electrophoresis and MALDI
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