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A8378

DL-2-烯丙基甘氨酸

Name: <SC>DL</SC>-2-烯丙基甘氨酸
Brand: SIGMA

别名:

(±)-2-氨基-4-戊烯酸, DL-C-烯丙基甘氨酸

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关于此项目

线性分子式:

H₂C=CHCH₂CH(NH₂)CO₂H

化学文摘社编号:

7685-44-1

分子量:

115.13

NACRES:

NA.26

PubChem Substance ID:

24891336

eCl@ss:

32160406

UNSPSC Code:

12352200

EC Number:

231-689-8

MDL number:

MFCD00063103

Beilstein/REAXYS Number:

1748645

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assay

≥98% (TLC)

form

powder

color

white

mp

258-260 °C (lit.)

application(s)

peptide synthesis

storage temp.

−20°C

SMILES string

NC(CC=C)C(O)=O

InChI

1S/C5H9NO2/c1-2-3-4(6)5(7)8/h2,4H,1,3,6H2,(H,7,8)

InChI key

WNNNWFKQCKFSDK-UHFFFAOYSA-N

Biochem/physiol Actions

DL-2-Allylglycine is a racemic mixture of L- and D-allylglycine. D-allylglycine is the enantiomer of L-allylglycine, a glutamate decarboxylase (GAD) inhibitor used in GABA research. D-allylglycine may be used as a control supplement versus L-allylglycine in GABA research. D-allylglycine is used in the organic synthesis of cyclic opioid peptide agonists and antagonists.

pictograms

GHS07

signalword

Warning

hcodes

H315,H317,H319,H335

pcodes

P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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分析证书(COA)

Lot/Batch Number

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Non-centrosymmetric racemates: space-group frequencies and conformational similarities between crystallographically independent molecules.

Dalhus B, Gorbitz CH.

Acta Physiologica Et Pharmacologica Bulgarica, 56, 715-719 (2000)

Allylglycine and brain excitability. Electrophysiological investigation in cats.

S Moyanova et al.

Acta physiologica et pharmacologica Bulgarica, 15(1), 47-53 (1989-01-01)

The effect of DL-allylglycine (DL-AG) in two doses (40 and 60 mg/kg i.v.) was studied on cats under acute conditions. DL-AG provoked the appearance of epileptiform EEG patterns either spontaneous or in response to intermittent light stimulation with a frequency

Disruption of GABAergic tone in the dorsomedial hypothalamus attenuates responses in a subset of serotonergic neurons in the dorsal raphe nucleus following lactate-induced panic.

Pl Johnson et al.

Journal of psychopharmacology (Oxford, England), 22(6), 642-652 (2008-03-01)

Panic patients are vulnerable to induction of panic attacks by sub-threshold interoceptive stimuli such as intravenous (i.v.) sodium lactate infusions. Facilitation of serotonergic signaling with selective serotonin reuptake inhibitors can suppress anxiety and panic-like responses, but the mechanisms involved are

Cyclic opioid peptide agonists and antagonists obtained via ring-closing metathesis.

Irena Berezowska et al.

Chemical biology & drug design, 74(4), 329-334 (2009-08-22)

The opioid peptide H-Tyr-c[D-Cys-Phe-Phe-Cys]NH(2) cyclized via a methylene dithiother is a potent and selective mu opioid agonist (Przydial M.J. et al., J Peptide Res, 66, 2005, 255). Dicarba analogues of this peptide with Tyr, 2',6'-dimethyltyrosine (Dmt), 3-[2,6-dimethyl-4-hydroxyphenyl)propanoic acid (Dhp) or

In vivo modulation of benzodiazepine receptor function after inhibition of endogenous gamma-aminobutyyric acid synthesis.

M Bottlaender et al.

European journal of pharmacology, 321(1), 13-17 (1997-02-19)

The influence of decreased endogenous gamma-aminobutyric acid (GABA) concentration on benzodiazepine receptor function was studied in the brain of living baboons. Positron emission tomography and the radiotracer [11C]flumazenil combined with electroencephalography were used to determine the pharmacological properties of two

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全球贸易项目编号

货号	GTIN
A8378-1G	04061826055861
A8378-10G	04061832415079
A8378-25G	04061832415086
A8378-5G	04061832415093

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