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Merck
CN

A8404

Sigma-Aldrich

盐酸阿米替林 盐酸盐

≥98% (TLC), norepinephrine and serotonin transporter inhibitor, powder

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关于此项目

经验公式（希尔记法）:
C20H23N · HCl
化学文摘社编号:
549-18-8
分子量:
313.86
EC 号:
208-964-6
MDL编号:
MFCD00012537
UNSPSC代码:
12352200
PubChem化学物质编号:
24278073
NACRES:
NA.77

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产品名称

盐酸阿米替林 盐酸盐, ≥98% (TLC), powder

质量水平

200

方案

≥98% (TLC)

表单

powder

颜色

white to off-white

溶解性

H2O: soluble
ethanol: soluble

创始人

Bristol-Myers Squibb

储存温度

2-8°C

SMILES字符串

Cl[H].CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

InChI key

KFYRPLNVJVHZGT-UHFFFAOYSA-N

基因信息

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133), SLC6A2(6530), SLC6A4(6532)

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相关类别

应用

盐酸阿密曲替林已用于：
  • 研究其作为抗抑郁药对酸性鞘磷脂酶转基因(t-ASM)小鼠社会行为和记忆的影响
  • 分析其作为三环类抗抑郁药物对人全血中糖皮质受体功能的影响
  • 研究其作为抗抑郁药对氯喹诱导小鼠搔抓和运动行为的影响

生化/生理作用

三环类抗抑郁药；去甲肾上腺素和5-羟色胺转运体抑制剂；对α1-肾上腺素能受体，5-羟色胺和毒蕈碱乙酰胆碱受体具有高体外亲和力。
三环类抗抑郁药；抑制去甲肾上腺素和5-羟色胺转运蛋白，Kis分别为100 nM和14.7 nM；对α1-肾上腺素能受体，5-羟色胺和毒蕈碱乙酰胆碱受体具有高体外亲和力。
盐酸阿密曲替林(Amitriptyline)可用于治疗焦虑、躁郁和更年期抑郁症。它具有抗组胺、抗胆碱和抗血清素特性。盐酸阿密曲替林是两亲性药物，具有神经抑制活性。

特点和优势

粉末的保质期至少为三年。

警示用语：

Danger

危险分类

Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Repr. 2

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN6293
BCCB7377
BCCH3794
BCBV1175
BCBQ4634V

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Iulia Zoicas et al.
PloS one, 11(9), e0162498-e0162498 (2016-09-07)
Major depressive disorder is often associated with deficits in social and cognitive functioning. Mice transgenic for acid sphingomyelinase (t-ASM) were previously shown to have a depressive-like phenotype, which could be normalized by antidepressant treatment. Here, we investigated whether t-ASM mice
Nadine Beckmann et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 43(4), 1460-1471 (2017-10-17)
Rheumatoid arthritis is a chronic autoimmune disease hallmarked by inflammation in synovial joints. Treatment is hampered by the lack of a cure and current disease-modifying drugs are associated with potentially severe toxicities. We investigated arthritis severity by measuring joint swelling
Neha Maurya et al.
Journal of biomolecular structure & dynamics, 35(6), 1367-1380 (2016-05-05)
Herein, we have explored the interaction between amitriptyline hydrochloride (AMT) and hemoglobin (Hb), using steady-state and time-resolved fluorescence spectroscopy, UV-visible spectroscopy, and circular dichroism spectroscopy, in combination with molecular docking and molecular dynamic (MD) simulation methods. The steady-state fluorescence reveals
Flow injection potentiometric determination of amitriptyline hydrochloride
El-Nashar R M, et al.
Microchemical Journal, Devoted to the Application of Microtechniques in All Branches of Science, 78(2), 107-113 (2004)
L A Carvalho et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 20(6), 379-387 (2010-03-17)
Clinical studies have demonstrated an impairment of glucocorticoid receptor (GR)-mediated negative feedback on the hypothalamic-pituitary-adrenal (HPA) axis in patients with major depression (GR resistance), and its resolution by antidepressant treatment. Recently, we showed that this impairment is indeed due to
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