A8625
N -乙酰基- D -氨基葡萄糖
≥99% (HPLC)
别名:
2-乙酰氨基-2-脱氧-D-葡萄糖, D-GlcNAc
生物来源
crab (red)
质量水平
方案
≥99% (HPLC)
表单
powder
技术
HPLC: suitable
颜色
white to off-white
mp
211 °C (dec.) (lit.)
溶解性
H2O: 50 mg/mL, clear to very slightly hazy (colorless to faint yellow solution)
储存温度
−20°C
SMILES字符串
CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O
InChI
1S/C8H15NO6/c1-3(11)9-5-7(13)6(12)4(2-10)15-8(5)14/h4-8,10,12-14H,2H2,1H3,(H,9,11)/t4-,5-,6-,7-,8?/m1/s1
InChI key
OVRNDRQMDRJTHS-RTRLPJTCSA-N
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一般描述
N-乙酰葡糖胺(GlcNAc)是葡糖胺(GlcN)的乙酰化衍生物。它是蛋白聚糖、糖蛋白、糖胺聚糖(GAG)和结缔组织中的其他合成单体的重要成分。
应用
N-乙酰-D-葡萄糖胺已用于:
- 用作凝集素组织化学竞争性抑制糖
- 用作培养伯氏疏螺旋体螺旋体菌(Borrelia burgdorferi spirochetes)株的 Barbour-Stonner-Kelly (BSK) 培养基成分
- 用作重悬肺炎链球菌(Streptococcus pneumoniae)菌株的结合缓冲液成分,以便通过抑制测定检验M-ficolin纤维胶凝蛋白与肺炎链球菌(S. pneumoniae )菌株结合的特异性
生化/生理作用
N-乙酰葡糖胺(GlcNAc)主要用于食品、化妆品和制药行业。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Mikkel Girke Jørgensen et al.
Genes & development, 27(10), 1132-1145 (2013-05-15)
Many bacterial small RNAs (sRNAs) regulate gene expression through base-pairing with mRNAs, and it has been assumed that these sRNAs act solely by this one mechanism. Here we report that the multicellular adhesive (McaS) sRNA of Escherichia coli uniquely acts
Colette Cywes-Bentley et al.
Proceedings of the National Academy of Sciences of the United States of America, 110(24), E2209-E2218 (2013-05-30)
Microbial capsular antigens are effective vaccines but are chemically and immunologically diverse, resulting in a major barrier to their use against multiple pathogens. A β-(1→6)-linked poly-N-acetyl-d-glucosamine (PNAG) surface capsule is synthesized by four proteins encoded in genetic loci designated intercellular
Lucy G Weaver et al.
Carbohydrate research, 371, 68-76 (2013-03-26)
Poly-N-acetylglucosamine (PNAG) saccharides are an important constituent of bacterial biofilms, such as those produced by Staphylococcus aureus. We have developed a simple two-step iterative method for the synthesis of β-(1→6)-glucosamine oligosaccharides that are structurally similar to PNAG. We illustrate the
Kwang-Hyup Lee et al.
Tissue & cell, 48(4), 361-369 (2016-05-29)
The morphological characteristics and glycoconjugate composition of the vomeronasal organ (VNO) of the horse was investigated using histological, immunohistochemical, and lectin histochemical methods. The VNO is bilaterally located at the base of the nasal septum, has a tubular structure surrounded
Gerald W Hart et al.
Nature, 446(7139), 1017-1022 (2007-04-27)
All animals and plants dynamically attach and remove O-linked beta-N-acetylglucosamine (O-GlcNAc) at serine and threonine residues on myriad nuclear and cytoplasmic proteins. O-GlcNAc cycling, which is tightly regulated by the concerted actions of two highly conserved enzymes, serves as a
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