biological source
human plasma
Quality Level
assay
≥70% protein basis (biuret)
form
salt-free, lyophilized powder
storage temp.
2-8°C
Gene Information
human ... ELA2(1991), SERPINA1(5265)
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Biochem/physiol Actions
1-4mg可抑制1.0mg胰蛋白酶（每mg蛋白大约10,000 BAEE单位活性）。1-6mg可抑制1.0mg α-胰凝乳蛋白酶（每mg蛋白>=40 BTEE单位活性）。
丝氨酸蛋白酶抑制剂；抑制胰蛋白酶、胰凝乳蛋白酶、胰和粒细胞弹性蛋白酶，以及顶体酶。有效浓度与蛋白酶等摩尔。
丝氨酸蛋白酶抑制剂；抑制胰蛋白酶、胰凝乳蛋白酶和胰腺和粒细胞弹性蛋白酶、以及顶体酶。有效浓度与蛋白酶等摩尔。遗传性 α1-抗胰蛋白酶缺乏的影响和某些自身免疫状态是由体内不受控制的蛋白水解引起的。Direct α1-抗胰蛋白酶替代疗法在1型糖尿病的动物模型中具有应用前景。
Preparation Note
经色谱法制备和部分纯化。
Disclaimer
仅供研究使用。本品在法国的科研应用受到监管，包括用于进口和出口活动（法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2）。如《公共卫生法典》所述，购买者（即最终用户）需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。
含有0.01％NaN3的水溶液可稳定几个月。溶液可在−80 °C下储存，但不应重新冷冻。其在pH 5.5以下不稳定。其可由一些非丝氨酸蛋白酶，以及氧化活性位点的甲硫氨酸残基进行灭活。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
高风险级别生物产品--人源产品
此项目有
Roy B Lefkowitz et al.
Analytical chemistry, 82(19), 8251-8258 (2010-09-11)
The ability to measure protease activity in the blood is important for the development of future diagnostics and for biomedical research. Presently, protease assays require sample preparation, making them time-consuming, costly, less accurate, and unsuitable for point-of-care (POC) diagnostics. Recently
M Wasil et al.
The Biochemical journal, 243(3), 867-870 (1987-05-01)
Thiourea and dimethylthiourea are powerful scavengers of hydroxyl radicals (.OH), and dimethylthiourea has been used to test the involvement of .OH in several animal models of human disease. It is shown that both thiourea and dimethylthiourea are scavengers of HOCl
B Halliwell et al.
FEBS letters, 213(1), 15-17 (1987-03-09)
Ascorbic acid, at physiological concentrations, can scavenge the myeloperoxidase-derived oxidant hypochlorous acid at rates sufficient to protect alpha 1-antiprotease against inactivation by this molecule. The rapid depletion of ascorbic acid at sites of inflammation, as in the inflamed rheumatoid joint
B M Bany et al.
Biology of reproduction, 47(4), 514-519 (1992-10-01)
The objective of this study was to investigate the uterine uptake of plasma alpha 1-proteinase inhibitor (53,000 Da) and alpha 2-macroglobulin (725,000 Da) from the blood during implantation in the mouse using isotopic methods. The uterine uptake of albumin (67,000
M Reist et al.
FEBS letters, 423(2), 231-234 (1998-03-25)
Sulphite is toxic to the lung and can cause allergic reactions, the most common of which is bronchoconstriction in asthmatics. We show that sulphite can considerably potentiate the inactivation of alpha1-antiproteinase caused by peroxynitrite. Addition of peroxynitrite to sulphite generated
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Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.
实验方案
Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。
相关内容
QC Methods
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A9024-100MG | 04061833627754 |
| A9024-25MG | 04061833401194 |
| A9024-5MG | 04061833258484 |
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