Anti-phospho-APP (pThr⁶⁶⁸) antibody produced in rabbit

Amyloid precursor proteins (APPs) are transmembrane glycoproteins that are found in a wide range of tissues. APPs have 3 main isoforms, namely, APP695, APP751 and APP770 that are derived from alternative splicing events in cells. Accumulation of the cleavage products of APP, such as the β-amyloid peptide, can cause Alzheimer′s disease.
Rabbit Anti-phospho-APP (pThr⁶⁶⁸⁾ antibody binds to human APP phosphorylated at Thr⁶⁶⁸. Mouse, rat and frog APP are 100% homologous.

synthetic phosphopeptide corresponding to the region of APP containing threonine 688.

Cultured cortical neurons were immunostained for APP using rabbit anti-phospho-APP (pThr688) antibody.

Rabbit Anti-phospho-APP (pThr⁶⁶⁸) antibody can be used for western blot applications at a dilution of 1:1,000.

Solution in Dulbecco′s phosphate buffered saline (without Mg²⁺ and Ca²⁺), pH 7.3, with 50% glycerol, 1.0 mg/mL BSA (IgG and protease free) and 0.05% sodium azide.

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