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Merck
CN

A9135

花生四烯酸乙酯

≥98.5% (GC), liquid

别名:

5,8,11,14-二十碳四烯酸乙酯, 花生四烯酸乙酯

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关于此项目

经验公式(希尔记法):
C22H36O2
化学文摘社编号:
分子量:
332.52
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
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产品名称

花生四烯酸乙酯, ≥98.5% (GC), liquid

InChI

1S/C22H36O2/c1-3-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22(23)24-4-2/h8-9,11-12,14-15,17-18H,3-7,10,13,16,19-21H2,1-2H3/b9-8-,12-11-,15-14-,18-17-

SMILES string

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)OCC

InChI key

SNXPWYFWAZVIAU-GKFVBPDJSA-N

biological source

fungus

assay

≥98.5% (GC)

form

liquid

functional group

ester

lipid type

omega FAs

shipped in

ambient

storage temp.

−20°C

Quality Level

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Biochem/physiol Actions

花生四烯酸(AA)是细胞膜磷脂的多不饱和Ω-6脂肪酸成分。磷脂酶A2响应炎症从膜磷脂释放AA。AA可在至少两种环加氧酶(COX)亚型作用下随后代谢成前列腺素和血栓素,被脂氧合酶代谢为白三烯和脂氧素,以及通过p450催化代谢为环氧二十碳三烯酸。 AA及其代谢物在多种生物过程中具有重要作用,包括信号转导、收缩、趋化性、以及细胞增殖、分化和凋亡。已证明AA与G蛋白的α亚基结合并抑制Ras GTPase激活蛋白(GAPs)的活性。 AA的细胞摄取需要消耗能量并且涉及涉及跨细胞质膜的蛋白质辅助转运。

Packaging

密封安瓿包装。

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Hao Wang et al.
Alcohol (Fayetteville, N.Y.), 83, 29-35 (2019-06-09)
Problems of stability were found for biomarkers of alcohol consumption: ethyl glucuronide (EtG), ethyl sulfate (EtS), phosphatidylethanols (PEths), and fatty acid ethyl esters (FAEEs) in whole blood. The purpose of this study was to establish a method for the determination
Enrique M Ostrea et al.
Alcoholism, clinical and experimental research, 30(7), 1152-1159 (2006-06-24)
Biomarkers of fetal exposure to alcohol are important to establish so that early detection and intervention can be made on these infants to prevent undesirable outcomes. The aim of this study was to analyze long-chain fatty acid ethyl esters (FAEEs)
D L Luthria et al.
Lipids, 28(9), 853-856 (1993-09-01)
Ethyl 5,8,11,14-eicosatetraenoate-19,19,20,20-d4 and ethyl 8,11,14-eicosatrienoate-19,19,20,20-d4 were synthesized by Grignard coupling of the methanesulfonyl ester of 2,5-undecadiyn-1-ol-10,10,11,11-d4 with 5,8-nonadiynoic acid and 8-nonynoic acid, respectively. The coupled products upon Lindlar reduction, followed by the preparation of their ethyl esters, yielded deuteriated ethyl
Eiichiro Ishido et al.
Bioscience, biotechnology, and biochemistry, 66(1), 73-77 (2002-02-28)
Two polyunsaturated fatty acids (PUFAs) or their esters were mixed, and their oxidation processes were measured at 65 degrees C and ca. 0% relative humidity. Except when a PUFA ester was mixed with a free PUFA, the oxidation of the
O Holian et al.
Biochemical and biophysical research communications, 160(3), 1110-1116 (1989-05-15)
Purified rat pancreas protein kinase C (PKC) is activated by unsaturated free fatty acids (oleic and arachidonic). The ethyl esters of these fatty acids are ineffective as enzyme activators. However, when the ethyl esters are added in combination with a

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