A9285
α1-Antichymotrypsin 来源于人类血浆
≥92.5% (SDS-PAGE), lyophilized powder
产品名称
α1-Antichymotrypsin 来源于人类血浆, ≥92.5% (SDS-PAGE), lyophilized powder
biological source
human plasma
assay
≥92.5% (SDS-PAGE)
form
lyophilized powder
mol wt
55-66 kDa
technique(s)
microbiological culture: suitable
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... SERPINA3(12)
Packaging
Package size based on protein content.
Physical form
Lyophilized powder containing Tris buffer salt and NaCl.
Application
α1-Antichymotrypsin from human plasma has been used as a component in yeast extract peptone dextrose broth (YEPD) for biofilm dispersion assays.
Biochem/physiol Actions
α1-Antichymotrypsin (α1-ACT) can block the functions of various serine proteases like chymotrypsin and cathepsin G. It serves as a potential therapeutic target of endometrial carcinoma (EC).
Specific inhibitor of chymotrypsin-like serine proteases.
Specific inhibitor of chymotrypsin-like serine proteases. Promotes amyloid-β polymerization in vitro and in vivo. Levels in plasma and cerebrospinal fluid have been found to correlate with progression of dementia in Alzheimer′s patients and induce phosphorylation of tau protein in neurons.
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
General description
α1-Antichymotrypsin (α1-ACT) is also known as serpin peptidase inhibitor, clade A member 3 (SERPINA3). It is a 68 kDa serine protease inhibitor, secreted by the liver. It belongs to the serpin superfamily of protease inhibitors. SERPINA3 is located on human chromosome 14q32.1.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
高风险级别生物产品--人源产品
此项目有
Human plasma proteinase inhibitors.
J Travis et al.
Annual review of biochemistry, 52, 655-709 (1983-01-01)
Is Alpha-1 Antichymotrypsin Gene Polymorphism a Risk Factor for Primary Intracerebral Hemorrhage? A Case-Control Study and Meta-Analysis
Hu X, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 2149-2149 (2015)
Up-regulation of SERPINA3 correlates with high mortality of melanoma patients and increased migration and invasion of cancer cells.
Zhou J, et al.
Oncotarget, 8(12), 18712-18712 (2017)
Brandon M Childers et al.
Infection and immunity, 81(11), 4112-4120 (2013-08-28)
Biofilm formation and persistence are essential components for the continued survival of pathogens inside the host and constitute a major contributor to the development of chronic wounds with resistance to antimicrobial compounds. Understanding these processes is crucial for control of
Saliva proteins of vector Culicoides modify structure and infectivity of bluetongue virus particles.
Karin E Darpel et al.
PloS one, 6(3), e17545-e17545 (2011-03-23)
Bluetongue virus (BTV) and epizootic haemorrhagic disease virus (EHDV) are related orbiviruses, transmitted between their ruminant hosts primarily by certain haematophagous midge vectors (Culicoides spp.). The larger of the BTV outer-capsid proteins, 'VP2', can be cleaved by proteases (including trypsin
商品
Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.
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