A9361
蒿甲醚
≥98% (HPLC)
别名:
SM-224, 二氢青蒿素甲醚, 甲基还原青蒿素
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关于此项目
经验公式（希尔记法）:
C16H26O5
化学文摘社编号:
分子量:
298.37
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51101908
MDL number:
产品名称
蒿甲醚, ≥98% (HPLC)
InChI key
SXYIRMFQILZOAM-HVNFFKDJSA-N
SMILES string
CO[C@H]1OC2O[C@@]3(C)CCC4[C@H](C)CCC([C@H]1C)[C@@]24OO3
InChI
1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D +155 to +175°, c = 0.5 in methanol
color
off-white to light brown
solubility
DMSO: ≥20 mg/mL
originator
Novartis
storage temp.
room temp
Quality Level
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Application
蒿甲醚已被用于：
- 作为抗血吸虫化合物测试其对幼虫期曼氏血吸虫的作用
- 提高小鼠胚胎成纤维细胞 (MEF) 和人骨肉瘤HT1080 细胞对半胱氨酸饥饿 (STV) 引起的铁死亡的敏感性
- 刺激胰岛及其对α到β分化转移的作用
Biochem/physiol Actions
蒿甲醚是一种抗疟疾化合物。
蒿甲醚是青蒿素的一种甲醚衍生物。它可用于治疗疟疾寄生虫恶性疟原虫的多重耐药菌株，并显示出治疗血吸虫病的潜力。
青蒿素含有具备高反应活性的内过氧化合物桥，这种桥结构是其治疗潜力的核心。内过氧化合物键与疟原虫红细胞中的铁反应。 这导致产生直接靶向疟原虫的活性氧（ROS）。 青蒿素还可调节肿瘤细胞中的铁死亡。α蒿甲醚可减少细胞转录因子Arx 的表达。初生胰岛的长期暴露还会导致难以鉴定内分泌细胞类型及其功能。
General description
青蒿素 (ART) 是一种存在于传统中草药青蒿中的天然化合物。
wgk
WGK 3
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Org. Perox. D
存储类别
5.2 - Organic peroxides and self-reacting hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
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Bart M J De Spiegeleer et al.
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商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
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