A9361
蒿甲醚
≥98% (HPLC)
别名:
SM-224, 二氢青蒿素甲醚, 甲基还原青蒿素
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经验公式（希尔记法）:
C16H26O5
化学文摘社编号:
分子量:
298.37
MDL编号:
UNSPSC代码:
51101908
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D +155 to +175°, c = 0.5 in methanol
颜色
off-white to light brown
溶解性
DMSO: ≥20 mg/mL
创始人
Novartis
储存温度
room temp
SMILES字符串
CO[C@H]1OC2O[C@@]3(C)CCC4[C@H](C)CCC([C@H]1C)[C@@]24OO3
InChI
1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13+,14-,15-,16-/m1/s1
InChI key
SXYIRMFQILZOAM-HVNFFKDJSA-N
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一般描述
青蒿素 (ART) 是一种存在于传统中草药青蒿中的天然化合物。
应用
蒿甲醚已被用于：
- 作为抗血吸虫化合物测试其对幼虫期曼氏血吸虫的作用
- 提高小鼠胚胎成纤维细胞 (MEF) 和人骨肉瘤HT1080 细胞对半胱氨酸饥饿 (STV) 引起的铁死亡的敏感性
- 刺激胰岛及其对α到β分化转移的作用
生化/生理作用
蒿甲醚是一种抗疟疾化合物。
蒿甲醚是青蒿素的一种甲醚衍生物。它可用于治疗疟疾寄生虫恶性疟原虫的多重耐药菌株，并显示出治疗血吸虫病的潜力。
青蒿素含有具备高反应活性的内过氧化合物桥，这种桥结构是其治疗潜力的核心。内过氧化合物键与疟原虫红细胞中的铁反应。 这导致产生直接靶向疟原虫的活性氧（ROS）。 青蒿素还可调节肿瘤细胞中的铁死亡。α蒿甲醚可减少细胞转录因子Arx 的表达。初生胰岛的长期暴露还会导致难以鉴定内分泌细胞类型及其功能。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Org. Perox. D
储存分类代码
5.2 - Organic peroxides and self-reacting hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Karina Knudsmark Jessing et al.
Journal of agricultural and food chemistry, 59(21), 11735-11743 (2011-10-04)
The area cultivated with Artemisia annua for the extraction of the antimalarial compound artemisinin is increasing, but the environmental impact of this cultivation has not yet been studied. A sensitive and robust method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was
Bart M J De Spiegeleer et al.
Journal of pharmaceutical and biomedical analysis, 70, 111-116 (2012-07-10)
During the stability evaluation of β-artemether containing finished drug products, a consistent and disproportional increase in the UV-peak areas of β-artemether degradation products, when compared to the peak area decline of β-artemether itself, was observed. This suggested that the response
André Lin Ouédraogo et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 60(3), 357-365 (2014-11-22)
Artemisinin combination therapy effectively clears asexual malaria parasites and immature gametocytes but does not prevent posttreatment malaria transmission. Ivermectin (IVM) may reduce malaria transmission by killing mosquitoes that take blood meals from IVM-treated humans. In this double-blind, placebo-controlled trial, 120
Talitha van der Meulen et al.
Cell metabolism, 27(1), 218-225 (2017-11-07)
Pancreatic α cells retain considerable plasticity and can, under the right circumstances, transdifferentiate into functionally mature β cells. In search of a targetable mechanistic basis, a recent paper suggested that the widely used anti-malaria drug artemether suppresses the α cell
Shuhua Xiao et al.
Acta tropica, 82(2), 175-181 (2002-05-22)
Two decades ago, a group of Chinese scientists discovered the antischistosomal properties of artemether, a derivative of the antimalarial drug artemisinin. However, it was only recently that the importance of this finding was recognized internationally, following a collaborative effort between
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