A9376
腺苷 2′:3′-循环磷酸钠盐 钠盐
≥93%, synthetic (organic), powder
别名:
2′,3′-循环磷酸钠盐
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关于此项目
线性分子式:
C10H11N5O6PNa
化学文摘社编号:
分子量:
351.19
EC 号:
MDL编号:
UNSPSC代码:
41106305
eCl@ss:
32160414
PubChem化学物质编号:
NACRES:
NA.51
产品名称
腺苷 2′:3′-循环磷酸钠盐 钠盐, ≥93%
生物来源
synthetic (organic)
质量水平
方案
≥93%
表单
powder
溶解性
water: 50 mg/mL, clear, colorless
储存温度
−20°C
SMILES字符串
[Na+].Nc1ncnc2n(cnc12)[C@@H]3O[C@H](CO)[C@H]4OP([O-])(=O)O[C@@H]34
InChI
1S/C10H12N5O6P.Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7-6(4(1-16)19-10)20-22(17,18)21-7;/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1
InChI key
VSDSIACSNXHGOV-MCDZGGTQSA-M
相关类别
应用
腺苷2′:3′-环单磷酸钠盐已用于亲和纯化应用的裂解缓冲液，同时用于微量热泳动测量。此外，它还被用于黄粉虫管的电生理研究。
生化/生理作用
腺苷2′,3′-环单酸酯(2′,3′-cAMP) 被视为腺苷的细胞外来源。 2′,3′-cAMP作为损伤响应在细胞外释放。2′,3′-cAMP可用于研究其降解酶在独特生物活性背景下的分布和特异性。2′,3′-cAMP也可用于研究诱导细胞凋亡的线粒体通透性过渡水平。2′,3′-cAMP被转换为2′-AMP和3′-AMP，从而通过A2B受体抑制肾小球前血管平滑肌细胞和肾小球系膜细胞的增殖。
免责声明
警告：请勿与普通的腺苷2′(3′)-单磷酸酯（混合异构体）混淆。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Edwin K Jackson
American journal of physiology. Renal physiology, 301(6), F1160-F1167 (2011-09-23)
Our recent studies employing HPLC-tandem mass spectrometry to analyze venous perfusate from isolated, perfused kidneys demonstrate that intact kidneys produce and release into the extracellular compartment 2',3'-cAMP, a positional isomer of the second messenger 3',5'-cAMP. To our knowledge, this represents
Edwin K Jackson et al.
The Journal of biological chemistry, 284(48), 33097-33106 (2009-10-06)
We discovered that renal injury releases 2',3'-cAMP (positional isomer of 3',5'-cAMP) into the interstitium. This finding motivated a novel hypothesis: renal injury leads to activation of an extracellular 2',3'-cAMP-adenosine pathway (i.e. metabolism of extracellular 2',3'-cAMP to 3'-AMP and 2'-AMP, which
T Uchida et al.
Biochimica et biophysica acta, 657(2), 356-363 (1981-02-13)
The sulphatase A (aryl-sulphate sulphohydrolase, EC 3.1.6.1) of ox liver hydrolyses adenosine 3',5'-monophosphate (cyclic AMP) to adenosine 5'-phosphate at an optimum pH of approx. 4.3, close that for the hydrolysis of cerebroside sulphate, a physiological substrate for sulphatase A. The
C Shen et al.
Journal of molecular evolution, 31, 445-452 (1990-01-01)
The prebiotic synthesis of His and its dimer has led us to study the possible catalytic properties of His-His. The enhancing effect of His-His has been tested in the dephosphorylation of dAMP, the hydrolysis of oligo(A)12, and the oligomerization of
Sandrine Evellin et al.
Methods in molecular biology (Clifton, N.J.), 284, 259-270 (2004-06-03)
cAMP is a ubiquitous second messenger that controls numerous cellular events including movement, growth, metabolism, contraction, and synaptic plasticity. With the emerging concept of compartmentalization of cAMP-dependent signaling, a detailed study of the spatio-temporal intracellular dynamics of cAMP is required.
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