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A9415

放线菌素D

Name: 放线菌素D
Brand: SIGMA

from Streptomyces sp., suitable for cell culture, ≥95%

别名:

放线菌素C₁, 放线菌素IV, 更生霉素

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关于此项目

经验公式（希尔记法）:

C₆₂H₈₆N₁₂O₁₆

化学文摘社编号:

50-76-0

分子量:

1255.42

UNSPSC Code:

51282001

NACRES:

NA.76

PubChem Substance ID:

24891447

EC Number:

200-063-6

Beilstein/REAXYS Number:

605235

MDL number:

MFCD00005033

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biological source

Streptomyces sp.

Quality Level

300

assay

≥95%

form

powder

technique(s)

cell culture | mammalian: suitable

mp

251-253

solubility

ethanol, DMSO: soluble (Stable in aqueous solutions at 2-8 °C.)

antibiotic activity spectrum

neoplastics

mode of action

DNA synthesis | interferes

storage temp.

2-8°C

SMILES string

CC(C)[C@H]1NC(=O)[C@@H](NC(=O)c2ccc(C)c3OC4=C(C)C(=O)C(N)=C(C(=O)N[C@H]5[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]6CCCN6C(=O)[C@H](NC5=O)C(C)C)C4=Nc23)[C@@H](C)OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]7CCCN7C1=O

InChI

1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)/t33-,34-,36+,37+,42-,43-,44+,45+,48+,49+/m1/s1

InChI key

RJURFGZVJUQBHK-IIXSONLDSA-N

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General description

化学结构：肽

Application

放线菌素 D 是一种抑制细胞增殖的抗肿瘤抗生素，具有广泛的应用，包括作为细胞培养中的选择剂，用在抑制 HIV 复制和 PC12 细胞程序性死亡的研究中。细胞培养应用的使用浓度推荐为 1μg/mL。

Biochem/physiol Actions

放线菌素 D 通过与双链 DNA 形成稳定的复合物，抑制 DNA 引发的 RNA 合成并引起 DNA 的单链断裂来抑制细胞的增殖。研究表明，它是逆转录酶中负链转移步骤的抑制剂。

Preparation Note

放线菌素 D 以红色、有光泽的晶体形式出售，可溶于乙腈或丙酮，浓度为 10 mg/mL，溶于 DMSO 中最低浓度为 1 mg/mL。一些参考文献还显示出在水中的微弱溶解度为 0.5 mg/mL。

Other Notes

保存于密闭容器内，置于干燥通风处。置于干燥处保存。

Disclaimer

该产品具有吸湿性和光敏性。如果在 2-8°C 下避光保存，经 HPLC 测试，可保持至少 15 个月。未使用的放线菌素 D 稀溶液对光极为敏感，容易吸附到塑料和玻璃上，应丢弃。但是，浓缩原液的冷冻等分试样至少可以稳定一个月。

pictograms

GHS06,GHS08

signalword

Danger

hcodes

H300,H350,H360FD

pcodes

P202 - P264 - P280 - P301 + P310 - P405 - P501

Hazard Classifications

Acute Tox. 2 Oral - Carc. 1B - Repr. 1B

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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全球贸易项目编号

货号	GTIN
A9415-10MG	04061833402481
A9415-2MG	04061833402498
A9415-25MG	04061833282373
A9415-5MG	04061833402504

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