A9434
氯化铵
Molecular Biology, suitable for cell culture, ≥99.5%
别名:
卤砂
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关于此项目
线性分子式:
NH4Cl
化学文摘社编号:
分子量:
53.49
NACRES:
NA.31
PubChem Substance ID:
eCl@ss:
38050207
UNSPSC Code:
12352302
EC Number:
235-186-4
MDL number:
Beilstein/REAXYS Number:
4371014
Assay:
≥99.5%
Grade:
Molecular Biology
Form:
powder or crystals
InChI key
NLXLAEXVIDQMFP-UHFFFAOYSA-N
InChI
1S/ClH.H3N/h1H;1H3
grade
Molecular Biology
vapor density
1.9 (vs air)
vapor pressure
1 mmHg ( 160.4 °C)
assay
≥99.5%
form
powder or crystals
technique(s)
cell culture | mammalian: suitable
mp
340 °C (subl.) (lit.)
anion traces
phosphate (PO43-): ≤2 ppm, sulfate (SO42-): ≤20 ppm
cation traces
Fe: ≤2 ppm, heavy metals (as Pb): ≤5 ppm
foreign activity
DNase, RNase, protease, none detected
Quality Level
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Application
氯化铵已可用于：
- 在vero细胞中作为内泌体酸化的抑制剂
- 作为血管平滑肌细胞(VSMC)的自噬抑制剂
- 在睾丸实质匀浆中红细胞的耗竭和裂解
Biochem/physiol Actions
氯化铵是氮循环的三个主要成分之一。氯化铵给药促进肌酐和尿素的清除 ，诱导小鼠代谢性酸中毒。过量的氯化铵会抑制大脑中kreb′s通路，并耗尽星形胶质细胞中的ATP。氯化铵抑制内溶酶体系统的酸化。氯化铵是一种溶血剂，用于红细胞的溶解。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Effect of ammonium chloride and dietary phosphorus in the azotaemic rat. I. Renal function and biochemical changes
Jara A, et al.
Nephrology, Dialysis, and Transplantation, 19(8), 1986-1992 (2004)
Aqueous ammonia and ammonium chloride hydrates: Principal infrared spectra
Max JJ and Chapados C
Journal of Molecular Structure, 1046, 124-135 (2013)
Nrf2 Activation Provides Atheroprotection in Diabetic Mice Through Concerted Upregulation of Antioxidant, Anti-inflammatory, and Autophagy Mechanisms
Lazaro I, et al.
Frontiers in Pharmacology, 9, 118-136 (2018)
Infectious bronchitis virus entry mainly depends on clathrin mediated endocytosis and requires classical endosomal/lysosomal system
Wang H, et al.
Virology, 528, 118-136 (2019)
Erythrocyte lysis in isotonic solution of ammonium chloride: Theoretical modeling and experimental verification
Chernyshev AV, et al.
Journal of Theoretical Biology, 251(1), 93-107 (2008)
实验方案
The GenElute Mammalian Genomic DNA Purification Kit Protocol describes the isolation of pure, high molecular weight DNA from a variety of mammalian sources.
GenElute 哺乳动物基因组 DNA 纯化方案阐述了从多种哺乳动物来源中分离纯高分子量 DNA 的方法。
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