生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 30 kDa
种属反应性
human
技术
western blot: 2-4 μg/mL using whole extract of human kidney 293 cells transfected with human Aph-1aL
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... APH1A(51107)
一般描述
Aph-1aL is a γ secretase subunit that facilitates the cleavage of several integral membrane proteins such as β-APP and Notch. Aph-1aL abnormalities have been associated with the risk of Alzheimer′s disease.
Rabbit Anti-Aph-1aL antibody recognizes Aph-1aL (30 kDa). Additional bands at approx. 46kDa and 20kDa may be observed in some cell extracts, which may represent Aph-1aL aggregation and degradation products, respectively.
Rabbit Anti-Aph-1aL antibody recognizes Aph-1aL (30 kDa). Additional bands at approx. 46kDa and 20kDa may be observed in some cell extracts, which may represent Aph-1aL aggregation and degradation products, respectively.
This sequence is identical in mouse Aph-1aL and not found in Aph-1aS and Aph-1b.
免疫原
synthetic peptide corresponding to amino acids 246-265 located at the C-terminus of human Aph-1aL.
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Rabbit Anti-Aph-1aL antibody has been used for western blot applications.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Kimberly, W.T., et al.
Proceedings of the National Academy of Sciences of the USA, 100, 6383-6387 (2002)
G W Scadding et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 40(4), 598-606 (2010-02-27)
The mechanisms of sublingual immunotherapy (SLIT) are less well understood than those of subcutaneous immunotherapy (SCIT). To determine the effects of grass-pollen SLIT on oral mucosal immune cells, local regulatory cytokines, serum allergen-specific antibody subclasses and B cell IgE-facilitated allergen
D J Selkoe
Current opinion in neurobiology, 10(1), 50-57 (2000-02-19)
Recent progress in elucidating the biology of Notch and presenilin has revealed a close functional relationship between these two proteins during cell fate determination in worms, flies and humans. Presenilins are required for the putatively intramembranous proteolysis of Notch to
Imran Khan et al.
Scientific reports, 8(1), 12834-12834 (2018-08-29)
Baculoviral protein expression in insect cells has been previously used to generate large quantities of a protein of interest for subsequent use in biochemical and structural analyses. The MultiBac baculovirus protein expression system has enabled, the use of a single
Hye-Ryun Lee et al.
Laboratory animal research, 28(2), 109-114 (2012-07-13)
Altered expression of neurotrophic factors as well as neuroinflammation is commonly associated with Major depressive disorder (MDD) and Alzheimer's disease (AD). To investigate whether or not reserpine-induced MDD affects the expression of AD-related proteins, the expression of γ-secretase components and
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