biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 30 kDa
species reactivity
human
technique(s)
western blot: 2-4 μg/mL using whole extract of human kidney 293 cells transfected with human Aph-1aL
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... APH1A(51107)
General description
Aph-1aL is a γ secretase subunit that facilitates the cleavage of several integral membrane proteins such as β-APP and Notch. Aph-1aL abnormalities have been associated with the risk of Alzheimer′s disease.
Rabbit Anti-Aph-1aL antibody recognizes Aph-1aL (30 kDa). Additional bands at approx. 46kDa and 20kDa may be observed in some cell extracts, which may represent Aph-1aL aggregation and degradation products, respectively.
Rabbit Anti-Aph-1aL antibody recognizes Aph-1aL (30 kDa). Additional bands at approx. 46kDa and 20kDa may be observed in some cell extracts, which may represent Aph-1aL aggregation and degradation products, respectively.
This sequence is identical in mouse Aph-1aL and not found in Aph-1aS and Aph-1b.
Immunogen
synthetic peptide corresponding to amino acids 246-265 located at the C-terminus of human Aph-1aL.
Application
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
Rabbit Anti-Aph-1aL antibody has been used for western blot applications.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Kimberly, W.T., et al.
Proceedings of the National Academy of Sciences of the USA, 100, 6383-6387 (2002)
G W Scadding et al.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 40(4), 598-606 (2010-02-27)
The mechanisms of sublingual immunotherapy (SLIT) are less well understood than those of subcutaneous immunotherapy (SCIT). To determine the effects of grass-pollen SLIT on oral mucosal immune cells, local regulatory cytokines, serum allergen-specific antibody subclasses and B cell IgE-facilitated allergen
D J Selkoe
Current opinion in neurobiology, 10(1), 50-57 (2000-02-19)
Recent progress in elucidating the biology of Notch and presenilin has revealed a close functional relationship between these two proteins during cell fate determination in worms, flies and humans. Presenilins are required for the putatively intramembranous proteolysis of Notch to
Hye-Ryun Lee et al.
Laboratory animal research, 28(2), 109-114 (2012-07-13)
Altered expression of neurotrophic factors as well as neuroinflammation is commonly associated with Major depressive disorder (MDD) and Alzheimer's disease (AD). To investigate whether or not reserpine-induced MDD affects the expression of AD-related proteins, the expression of γ-secretase components and
Imran Khan et al.
Scientific reports, 8(1), 12834-12834 (2018-08-29)
Baculoviral protein expression in insect cells has been previously used to generate large quantities of a protein of interest for subsequent use in biochemical and structural analyses. The MultiBac baculovirus protein expression system has enabled, the use of a single
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