A9607
Anti-ATP13A2 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-ATPase type 13A2, Anti-PARK9
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~129 kDa
species reactivity
mouse, human
enhanced validation
recombinant expression
Learn more about Antibody Enhanced Validation
concentration
~1 mg/mL
technique(s)
western blot: 1-2 μg/mL using mouse brain extract (S1 fraction), western blot: 2-4 μg/mL using extract of HEk-293T cells expressing human ATP13A2
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ATP13A2(23400)
mouse ... Atp13a2(74772)
rat ... Atp13a2(362645)
General description
ATP13A2 is a member of the P5 family of ATPases which function in the transport of inorganic cations.
ATPase type 13A2 (ATP13A2) is a neuronal P-type ATPAse. The gene is also referref as PARK9 (Parkinson′s disease 9).
Rabbit Anti-ATP13A2 antibody binds to human and mouse ATP13A2.
Application
Rabbit Anti-ATP13A2 antibody has been used for western blot assays.
Biochem/physiol Actions
Mutations in the gene encoding ATPase type 13A2 (ATP13A2) is implicated with a hereditary form of PD associated with dementia, known as Kufor-Rakeb syndrome (KRS). ATP13A2 shows elevated expression levels in brains of sporadic PD patients, suggesting a potential role in the more common forms of Parkinson′s disease.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
Patrick J Schultheis et al.
Human molecular genetics, 22(10), 2067-2082 (2013-02-09)
Mutations in ATP13A2 (PARK9), encoding a lysosomal P-type ATPase, are associated with both Kufor-Rakeb syndrome (KRS) and neuronal ceroid lipofuscinosis (NCL). KRS has recently been classified as a rare genetic form of Parkinson's disease (PD), whereas NCL is a lysosomal
Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase
Ramirez A, et al.
Nature Genetics, 38(10), 1184-1184 (2006)
Yuta Hatori et al.
PloS one, 17(11), e0276823-e0276823 (2022-11-30)
Mutations in ATP13A2 cause Kufor-Rakeb Syndrome (KRS), a juvenile form of Parkinson's Disease (PD). The gene product belongs to a diverse family of ion pumps and mediates polyamine influx from lysosomal lumen. While the biochemical and structural studies highlight its
Jason P Covy et al.
Journal of neuroscience research, 90(12), 2306-2316 (2012-08-01)
Mutations in ATP13A2, which encodes a lysosomal P-type ATPase of unknown function, cause an autosomal recessive parkinsonian syndrome. With mammalian cells, we show that ATP13A2 expression protects against manganese and nickel toxicity, in addition to proteasomal, mitochondrial, and oxidative stress.
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