A9736
A-438079 盐酸盐 水合物
≥98% (HPLC), P2X7 purinoceptor antagonist, powder
别名:
3-（5-（2,3-二氯苯基）-1H-四唑-1-基）甲基吡啶 盐酸盐 水合物
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关于此项目
经验公式（希尔记法）:
C13H9Cl2N5·HCl · xH2O
化学文摘社编号:
分子量:
342.61 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
A-438079 盐酸盐 水合物, ≥98% (HPLC)
SMILES string
O.Cl.Clc1cccc(c1Cl)-c2nnnn2Cc3cccnc3
InChI key
ZHFJJBAKSROKNO-UHFFFAOYSA-N
InChI
1S/C13H9Cl2N5.ClH.H2O/c14-11-5-1-4-10(12(11)15)13-17-18-19-20(13)8-9-3-2-6-16-7-9;;/h1-7H,8H2;1H;1H2
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 20 mg/mL, clear
originator
Abbott
storage temp.
2-8°C
Quality Level
相关类别
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Resident macrophages cloak tissue microlesions to prevent neutrophil-driven inflammatory damage
Uderhardt S, et al.
Cell, 177(3), 541-555 (2019)
Altered purinergic signaling in uridine adenosine tetraphosphate-induced coronary relaxation in swine with metabolic derangement
Zhou Z, et al.
Purinergic Signaling, 13(3), 319-329 (2017)
Kelaier Yang et al.
Frontiers in pharmacology, 11, 603689-603689 (2021-02-16)
Introduction: P2X7R excitation-interrelated NLRP3 inflammasome activation induced by high glucose contributes to the pathogenesis of diabetic retinopathy (DR). Relaxin-3 is a bioactive peptide with a structure similar to insulin, which has been reported to be effective in diabetic cardiomyopathy models
Haiyan Wang et al.
Journal of inflammation research, 13, 571-582 (2020-10-17)
Long-term use of morphine induces antinociceptive tolerance and limits its clinical efficacy. Neuroinflammation in the spinal cord is thought to play a pivotal role in the development of morphine tolerance. Toll-like receptor 4 (TLR4) and P2X7 receptor (P2X7R) are key
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