A9770
乙醛脱氢酶，钾-激活 来源于酵母
lyophilized powder, ≥10 units/mg protein
别名:
ALDH, 不依赖CoA的醛脱氢酶, 间甲基苯甲醛脱氢酶, 乙醛：NAD[P]+氧化还原酶
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-846-3
MDL number:
Specific activity:
≥10 units/mg protein
Biological source:
yeast
biological source
yeast
Quality Level
form
lyophilized powder
specific activity
≥10 units/mg protein
storage condition
(Tightly closed. Dry)
color
white
UniProt accession no.
foreign activity
NADH oxidase ≤0.01%, NADPH oxidase ≤0.01%, alcohol dehydrogenase ≤0.01%, lactic dehydrogenase ≤0.01%
storage temp.
2-8°C
General description
乙醛脱氢酶(ALDH)家族包含人类19个基因。它位于细胞的细胞核、细胞质、线粒体和内质网中。
研究领域：细胞信号传导
研究领域：细胞信号传导
酵母来源乙醛脱氢酶用于催化许多种底物氧化，比如乙醛、甲醛、丙醛、正丁醛、异丁醛、N-戊醛、己醛、苯甲醛、糖醛、D-甘油醛、丙二酸半醛和丁二酸醛。酵母来源乙醛脱氢酶用于研究乙醇和异丁醇生产。Sigma的乙醛脱氢酶可结合乙醇脱氢酶测定白色念珠菌(Candida albicans)糖酵解代谢和离子转运过程中的乙醇生产。
Application
酵母来源钾活化乙醛脱氢酶已用于：
- 固定酶和氧化甲醛以形成甲酸酯
- 研究与腙之间的作用关系
- 测定乙醇生成。
Biochem/physiol Actions
乙醛脱氢酶(ALDH)调节非P450醛还原酶系统。它可保护细胞免受有毒乙醛的影响。该基因的突变会导致Sjogren‐Larsson综合征、Larsson综合征、II型高脯胺酸血症和癌症。乙醛脱氢酶2可减轻心肌梗死或心脏手术后的心肌缺血性损伤。乙醛脱氢酶(ALDH)在免疫系统中参与调节性T细胞功能。还参与细胞解毒、氨基酸代谢，并保护细胞免遭紫外线(UV)诱导损伤。ALDH与视黄酸生物合成和信号传导有关。
乙醛脱氢酶是一种四聚体，有几种不同的亚型。乙醛脱氢酶被丙脲，巴豆醛，异氰酸正丙酯，异氰酸环己酯，1-n-丙基-1-[（4-氯苯基）磺酰]-3-n-丙基脲和1-甲基-1-[（4-氯苯基）磺酰]-3-n-丙基脲抑制。该酶在0.01M焦磷酸盐缓冲液中检测，表现为在pH9.3有最大峰值，乙醛为底物。
Physical form
含有磷酸钾盐
Other Notes
在pH 8.0、25摄氏度条件下，一单位每分钟可1微摩尔乙醛氧化为乙酸。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Novel dehydrogenase catalyzes oxidative hydrolysis of carbon-nitrogen double bonds for hydrazone degradation
Itoh H, et al.
The Journal of biological chemistry, 283(9), 5790-5800 (2008)
Christopher G Bazewicz et al.
Immunology, 156(1), 47-55 (2018-11-06)
The role of aldehyde dehydrogenase (ALDH) in carcinogenesis and resistance to cancer therapies is well known. Mounting evidence also suggests a potentially important role for ALDH in the induction and function of regulatory T (Treg) cells. Treg cells are important
Seung-Kyu Park et al.
Biomedical research (Tokyo, Japan), 30(5), 263-269 (2009-11-06)
Ethanol consumption disturbs the balance between the pro- and anti-oxidant systems of the organism, leading to oxidative stress. Electrolyzed-reduced water (ERW) is widely used by people in East Asia for drinking purposes because of its therapeutic properties including scavenging effect
Paper based biofuel cells: Incorporating enzymatic cascades for ethanol and methanol oxidation
Lau C, et al.
International Journal of Hydrogen Energy, 40(42), 14661-14666 (2015)
Xiao-Jun Ji et al.
Applied microbiology and biotechnology, 85(6), 1751-1758 (2009-09-17)
Ethanol was a major byproduct of 2,3-butanediol (2,3-BD) fermentation by Klebsiella oxytoca ME-UD-3. In order to achieve a high efficiency of 2,3-BD production, K. oxytoca mutants deficient in ethanol formation were successfully constructed by replace the aldA gene coding for
商品
Serotonin is stored in cells and metabolized by MAO, influencing CNS, GI, and platelet functions.
血清素（5-羟色胺）主要存在于三种主要细胞类型中：i）中杻神经系统（CNS）和肠肌间神经丛中的血清素能神经元，ii）胃肠道粘膜中的肠嗜铬细胞，和iii）血小板。血清素的代谢主要通过外部线粒体膜酶单胺氧化酶（MAO）进行，它以两种分子亚型存在，分别称为MAO-A和MAO-B。
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A9770-100UN | 04061833412343 |
| A9770-25UN | 04061833412367 |
| A9770-250UN | 04061833412350 |
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持