A9855
3-乙酰基-11-酮-β-乳香酸
from Boswellia serrata
别名:
AKBA
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关于此项目
经验公式（希尔记法）:
C32H48O5
化学文摘社编号:
分子量:
512.72
MDL number:
UNSPSC Code:
12352106
NACRES:
NA.25
biological source
Boswellia serrata
Quality Segment
form
powder
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
SMILES string
O([C@H]1[C@]([C@H]2[C@@]([C@@H]3[C@]([C@@]4(CC[C@@]5([C@@H]([C@H]([C@@H](CC5)C)C)C4=CC3=O)C)C)(CC2)C)(CC1)C)(C)C(=O)O)C(=O)C
InChI
1S/C32H48O5/c1-18-9-12-28(4)15-16-30(6)21(25(28)19(18)2)17-22(34)26-29(5)13-11-24(37-20(3)33)32(8,27(35)36)23(29)10-14-31(26,30)7/h17-19,23-26H,9-16H2,1-8H3,(H,35,36)/t18-,19+,23-,24-,25+,26-,28-,29+,30-,31-,32-/m1/s1
InChI key
HMMGKOVEOFBCAU-BCDBGHSCSA-N
General description
乙酰基-11-酮基-β-乳香酸（AKBA）是从 齿叶乳香树脂中提取的。
Application
3-乙酰基-11-酮基-β-乳香酸（AKBA）已被用于：
- 在体外模型中测试其作为抗增殖剂与伊马替尼联用对肝星状细胞 （HSC） 增殖和协同作用的影响
- 研究其对雌性 Sprague Dawley 大鼠卵巢切除引起的骨质疏松症的抗骨质疏松作用
- 在一项与阿司匹林的比较研究中测试其作为抗炎药在 APCMin/+ 小鼠中预防肠腺瘤性息肉病的作用
Biochem/physiol Actions
乙酰基-11-酮基-β-乳香酸是一种五环三萜，它能以选择性、酶定向、非氧化还原和非竞争性方式抑制5-脂氧合酶。它还可以抑制拓扑异构酶I和NF-κB 信号传导。
乙酰基-11-酮基-β-乳香酸（AKBA）分别对表皮葡萄球菌和 金黄色葡萄球菌有抗菌和抗生物膜活性。它是核因子E2 相关因子(Nrf2)的激活剂， 在体外和体内研究中具有针对缺血性损伤的神经保护特性。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Alsaba F Raja et al.
BMC microbiology, 11, 54-54 (2011-03-17)
Boswellic acids are pentacyclic triterpenes, which are produced in plants belonging to the genus Boswellia. Boswellic acids appear in the resin exudates of the plant and it makes up 25-35% of the resin. β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid
Ruiqi Wang et al.
Drug discoveries & therapeutics, 8(1), 25-32 (2014-03-22)
Acetyl-11-keto-beta-BA (AKBA), a component of the gum resin of Boswellia serrata, has been recognized as a promising agent for the prevention of intestinal tumorigenesis. Aspirin, a non-steroidal anti-inflammatory drug (NSAID), has also been considered to have the activity against intestinal
Mona Abdel-Tawab et al.
Clinical pharmacokinetics, 50(6), 349-369 (2011-05-11)
Non-steroidal anti-inflammatory drug (NSAID) intake is associated with high prevalence of gastrointestinal or cardiovascular adverse effects. All efforts to develop NSAIDs that spare the gastrointestinal tract and the cardiovasculature are still far from achieving a breakthrough. In the last two
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A9855-5MG | 04061832860831 |