A9899
盐酸安他唑啉 盐酸盐
别名:
2-(N-苄基苯胺基甲基)-2-咪唑啉 盐酸盐
表单
powder
质量水平
创始人
Novartis
SMILES字符串
Cl.C1CN=C(CN(Cc2ccccc2)c3ccccc3)N1
InChI
1S/C17H19N3.ClH/c1-3-7-15(8-4-1)13-20(14-17-18-11-12-19-17)16-9-5-2-6-10-16;/h1-10H,11-14H2,(H,18,19);1H
InChI key
SWKDMSRRIBZZAY-UHFFFAOYSA-N
基因信息
human ... HRH1(3269)
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生化/生理作用
咪唑啉激动剂；诱导 β 细胞释放胰岛素比依法克生更有效；H1 组胺受体拮抗剂
Imidazoline agonist; H1 histamine receptor antagonist.
特点和优势
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Influence of antazoline on the anticonvulsant activity of conventional antiepileptic drugs against maximal electroshock-induced seizures in mice.
M Swiader et al.
Polish journal of pharmacology, 51(1), 104-104 (1999-07-02)
T Ibbotson et al.
British journal of pharmacology, 110(4), 1556-1564 (1993-12-01)
1. In rat whole portal veins, guanabenz (100 nM to 10 microM) and antazoline (100 nM to 100 microM) each increased the amplitude, frequency and duration of spontaneous contractions. In addition, guanabenz (30 microM) and antazoline (30 microM) each antagonized
Neuroprotective activity of antazoline against neuronal damage induced by limbic status epilepticus.
D Milhaud et al.
Neuroscience, 120(2), 475-484 (2003-08-02)
Imidazoline drugs exert neuroprotective effects in cerebral ischaemia models. They also have effects against mouse cerebellar and striatal neuronal death induced by N-methyl-D-aspartate (NMDA) through the blockade of NMDA currents. Here, we investigated the effects of antazoline on NMDA toxicity
G Olmos et al.
British journal of pharmacology, 127(6), 1317-1326 (1999-08-24)
This study was designed to assess the potential neuroprotective effect of several imidazol(ine) drugs and agmatine on glutamate-induced necrosis and on apoptosis induced by low extracellular K+ in cultured cerebellar granule cells. Exposure (30 min) of energy deprived cells to
D Berdeu et al.
European journal of pharmacology, 254(1-2), 119-125 (1994-03-11)
The effects of imidazolines and derivatives were studied on insulin secretion and vascular resistance in the isolated perfused rat pancreas. On insulin secretion, two imidazoline alpha 2-adrenoceptor antagonists, efaroxan (1-100 microM) and RX821002 (10 microM), had a stimulating response; however
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