Biopredic′s HepaRG Maintenance and Metabolism Medium Supplement with Antibiotics can be used with all HepaRG cell lines. See user guide for detailed protocols.

HepaRG^™ cells uniquely maintain significant levels of hepatic cell functions, being CYP450 inducible and support the complete hepatitis B virus (HBV) replicative cycle.

HepaRG^™ maintenance and metabolism medium supplement with antibiotics has been used to culture HepaRG cells:

• to study the interaction of hepatocytes and cholangiocytes when challenged with chlorpromazine (CPZ)
• to assess the validity of stable reference genes (RG) for gene expression using quantitative real-time polymerase chain reaction (RT-qPCR)
• as a supplement in basal hepatic cell culture medium to study the effects of cholestasis on liver connexins

Use of this product is subject to one or more license agreements.

HepaRG cells are patented and their use is strictly limited; consider the cells as a single use, disposable product that must be destroyed upon conclusion of a study or experiment. Propagating, reproducing, cloning, subcloning or any other use of the cells following the conclusion of a study is prohibited. Use of the cells to produce or manufacture commercial products for general sale or for use in the manufacture of products intended for general sale is prohibited. Transfer of the cells to anyone not employed within the same organization, whether for financial benefit or not, is prohibited. If you are unwilling to accept the terms of this LIMITED USE LICENSE, do not ORDER or use them and immediately return the cells for credit. Violators of this Limited Use Licesense will be prosecuted to the fullest extent of the law.

HepaRG is a trademark of BioPredic International company