AV32362
Anti-TLE3 antibody produced in rabbit
IgG fraction of antiserum
别名:
Anti-Transducin-like enhancer of split 3 (E(sp1) homolog, Drosophila)
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
IgG fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
83 kDa
species reactivity
pig, dog, human, bovine
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TLE3(7090)
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General description
TLE3 is known to function as a transcriptional coregulator of adipogenesis. It interacts with HESX1 and PROP1 to regulate transcriptional expression.
Rabbit Anti-TLE3 antibody recognizes human, zebrafish, rat, mouse, and canine TLE3.
Rabbit Anti-TLE3 antibody recognizes human, zebrafish, rat, mouse, and canine TLE3.
Immunogen
Synthetic peptide directed towards the N terminal region of human TLE3
Application
Rabbit Anti-TLE3 antibody can be used for western blot applications at a concentration of 2.5μg/ml.
Biochem/physiol Actions
The TLE genes are differentially expressed and encode nuclear proteins, consistent with the presence of sequence motifs associated with nuclear functions. These genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway which controls a number of different cell-fate choices in invertebrates and vertebrates.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: GSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRA
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Luciani R Carvalho et al.
Molecular endocrinology (Baltimore, Md.), 24(4), 754-765 (2010-02-26)
Pituitary hormone deficiency causes short stature in one in 4000 children born and can be caused by mutations in transcription factor genes, including HESX1, PROP1, and POU1F1. HESX1 interacts with a member of the groucho-related gene family, TLE1, through an
Claudio J Villanueva et al.
Cell metabolism, 13(4), 413-427 (2011-04-05)
PPARγ and Wnt signaling are central positive and negative regulators of adipogenesis, respectively. Here we identify the groucho family member TLE3 as a transcriptional integrator of the PPARγ and Wnt pathways. TLE3 is a direct target of PPARγ that participates
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