KCNN1 (SK1) codes for a voltage-independent, calcium-activated channel integral membrane protein. This protein belongs to potassium channel family. Mouse SK1 protein can interact with calmodulin without the aid of Ca²⁺ ions.
Rabbit Anti-KCNN1 antibody recognizes human and bovine KCNN1.

Synthetic peptide directed towards the C terminal region of human KCNN1

Rabbit Anti-KCNN1 antibody is suitable for western blot applications at a concentration of 1.25 μg/ml.

Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. KCNN1 is a member of the KCNN family of potassium channels.

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Synthetic peptide located within the following region: KIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLD

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