CN
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
antibody product type
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
55 kDa
species reactivity
dog, bovine, human, guinea pig, rat, mouse
浓度
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
target post-translational modification
unmodified
Gene Information
human ... HDAC1(3065)
一般描述
Histone deacetylase 1 (HDAC1) is involved in the regulation of eukaryotic gene expression. HDAC1 is involved in the regulation of critical cell processes such as cell proliferation, differentiation and apoptosis. HDAC1 in association with other gene regulatory proteins regulates a wide range of specific gene cascades. For example HDAC1 is a regulator of retrotransposon expression in mouse embryonic stem cells. HDAC1 is the target of various histone deacetylase inhibitor under development as potential cancer therapeutic agent.
特异性
Anti-HDAC1 polyclonal antibody reacts with canine, human, mouse, rat, and bovine histone deacetylase 1 proteins.
免疫原
Synthetic peptide directed towards the C terminal region of human HDAC1
应用
Anti-HDAC1 polyclonal antibody is used to tag histone deacetylase 1 protein for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of histone deacetylase 1 in a variety of gene activation cascades and cellular processes.
生化/生理作用
Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. HDAC1 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. HDAC1 also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, HDAC1 deacetylates p53 and modulates its effect on cell growth and apoptosis.Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
序列
Synthetic peptide located within the following region: SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKP
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
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示例
T1503
货号
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25G
包装规格/数量
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Ilenia Aversa et al.
International journal of molecular sciences, 19(10) (2018-10-03)
Nuclear Factor-κB (NF-κB) is frequently activated in tumor cells contributing to aggressive tumor growth and resistance to chemotherapy. Here we demonstrate that Ferritin Heavy Chain (FHC) protein expression inversely correlates with NF-κB activation in cancer cell lines. In fact, FHC
Emma L Smith et al.
Nucleic acids research, 47(21), 11151-11163 (2019-10-11)
Phosphorylation of the NF-κB transcription factor is an important regulatory mechanism for the control of transcription. Here we identify serine 80 (S80) as a phosphorylation site on the p50 subunit of NF-κB, and IKKβ as a p50 kinase. Transcriptomic analysis
Fa-Xiu Chen et al.
International journal of biological sciences, 16(9), 1481-1494 (2020-04-01)
Inflammation and apoptosis are considered as two major pathological causes of human sarcopenia. The current understanding based on different models recognizes that apoptosis does not trigger inflammation, while emerging evidence indicates that inflammation can induce apoptosis. Here, we provide solid
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