AV39298
Anti-TRIT1 antibody produced in rabbit
affinity isolated antibody
别名:
Anti-tRNA isopentenyltransferase 1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
51 kDa
species reactivity
human
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Quality Level
Gene Information
human ... TRIT1(54802)
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General description
TRIT1 codes for a tRNA isopentenyltransferase that may be candidate lung tumor suppressor. Studies have reported that TRIT1 mutations can be a risk factor for gastric cancer in a Chinese population.
Rabbit Anti-TRIT1 antibody recognizes human TRIT1.
Rabbit Anti-TRIT1 antibody recognizes human TRIT1.
Immunogen
Synthetic peptide directed towards the C terminal region of human TRIT1
Application
Rabbit Anti-TRIT1 antibody has been used for immunoblotting assays at a dilution of 1:1000.
Biochem/physiol Actions
TRIT1 is responsible for the modification of A37 to isopentenyl A37 of both cytosolic and mitochondrial tRNAs.
Physical form
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Other Notes
Synthetic peptide located within the following region: SHLNQLKKRRRLDSDAVNTIESQSVSPDHNKEPKEKGSPGQNDQELKCSV
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Shuqin Chen et al.
Carcinogenesis, 34(5), 1018-1024 (2013-01-26)
To explore the association of polymorphisms in the region of three neighboring genes TRIT1, MYCL1 and MFSD2A with risk and clinicopathological features of gastric cancer, 19 tagging SNPs in this region were genotyped using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Monica Spinola et al.
Oncogene, 24(35), 5502-5509 (2005-05-05)
tRNA-isopentenyltransferase (tRNA-IPT) catalyses the addition of N6-isopentenyladenosine (i6A) on residue 37 of tRNA molecules that bind codons starting with uridine. Post-transcriptional modifications of tRNA molecules have been demonstrated to be essential in maintaining the correct reading frame of the translational
Noelia Fradejas et al.
The Biochemical journal, 450(2), 427-432 (2013-01-08)
Selenoproteins are proteins carrying the rare amino acid Sec (selenocysteine). Full expression of selenoproteins requires modification of tRNA([Ser]Sec), including N(6)-isopentenylation of base A(37). We show that Trit1 is a dimethylallyl:tRNA([Ser]Sec) transferase. Knockdown of Trit1 reduces expression of selenoproteins. Incubation of
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