AV49147
Anti-PIGW antibody produced in rabbit
affinity isolated antibody
别名:
Anti-FLJ37433, Anti-Gwt1, Anti-Phosphatidylinositol glycan anchor biosynthesis, class W
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
57 kDa
种属反应性
horse, human, guinea pig, bovine
浓度
0.5 mg - 1 mg/mL
技术
western blot: suitable
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
基因信息
human ... PIGW(284098)
免疫原
Synthetic peptide directed towards the middle region of human PIGW
应用
Anti-PIGW antibody produced in rabbit is suitable for western blotting at a concentration of 0.5μg/ml.
生化/生理作用
Phosphatidylinositol glycan anchor biosynthesis, class W (PIGW; Gwt1) mediates the acetylation of inositol ring of phosphatidylinositol during the biosynthesis of glycosylphosphatidylinositol (GPI). GPI acts as an anchor to cell surface proteins. Mutations in PIGW result in deficiency of GPI observed in West syndrome and hyperphosphatasia with mental retardation syndrome.
外形
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
其他说明
Synthetic peptide located within the following region: IALGITVLYQLALDFTSLKRLILYGTDGSGTRVGLLNANREGIISTLGYV
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Tomohiro Chiyonobu et al.
Journal of medical genetics, 51(3), 203-207 (2013-12-25)
Glycosylphosphatidylinositol (GPI) is a glycolipid that anchors 150 or more kinds of proteins to the human cell surface. There are at least 26 genes involved in the biosynthesis and remodelling of GPI anchored proteins (GPI-APs). Recently, inherited GPI deficiencies (IGDs)
Mariko Umemura et al.
The Journal of biological chemistry, 278(26), 23639-23647 (2003-04-26)
Glycosylphosphatidylinositol (GPI) is a conserved post-translational modification to anchor cell surface proteins to plasma membrane in all eukaryotes. In yeast, GPI mediates cross-linking of cell wall mannoproteins to beta1,6-glucan. We reported previously that the GWT1 gene product is a target
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