AV49429
抗-TMCO1 兔抗
affinity isolated antibody
别名:
抗-HP10122, 抗-PCIA3, 抗-PNAS-136, 抗-RP11-466F5.7, 抗-TMCC4, 抗-跨膜和卷曲螺旋结构域1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
western blot
Species reactivity:
mouse, bovine, horse, rat, dog, rabbit, human, guinea pig
Citations:
3
Technique(s):
western blot: suitable
Uniprot accession no.:
产品名称
抗-TMCO1 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
21 kDa
species reactivity
mouse, bovine, horse, rat, dog, rabbit, human, guinea pig
concentration
0.5 mg - 1 mg/mL
technique(s)
western blot: suitable
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TMCO1(54499)
Application
兔产生的抗-TMCO1抗体在1.0μg/ml浓度下适用于蛋白质印迹。
Biochem/physiol Actions
跨膜和卷曲螺旋结构域1（TMCO1）是DUF841超家族的膜蛋白。虽然该蛋白功能尚不清楚，但该基因的纯合移码突变会导致颅面先天性畸形、骨胳异常和智力障碍等。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
Immunogen
靶向人TMCO1 C末端区域的合成肽
Other Notes
合成肽位于以下区域内： CSFIFLYILCTMSIRQNIQKILGLAPSRAATKQAGGFLGPPPPSGKFS
Physical form
本品为溶于1x PBS缓冲液的纯化抗体，含 0.09% (w/v) 叠氮化钠和2%蔗糖。
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存储类别
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Baozhong Xin et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(1), 258-263 (2009-12-19)
We identified an autosomal recessive condition in 11 individuals in the Old Order Amish of northeastern Ohio. The syndrome was characterized by distinctive craniofacial dysmorphism, skeletal anomalies, and mental retardation. The typical craniofacial dysmorphism included brachycephaly, highly arched bushy eyebrows
Peace Atakpa et al.
Journal of cell science, 132(3) (2019-01-09)
The dipeptide glycyl-l-phenylalanine 2-naphthylamide (GPN) is widely used to perturb lysosomes because its cleavage by the lysosomal enzyme cathepsin C is proposed to rupture lysosomal membranes. We show that GPN evokes a sustained increase in lysosomal pH (pHly), and transient
Jianwei Li et al.
Nature communications, 10(1), 1589-1589 (2019-04-10)
Transmembrane and coiled-coil domains 1 (TMCO1) is a recently identified Ca2+ leak channel in the endoplasmic reticulum. TMCO1 dysfunction in humans is associated with dysmorphism, mental retardation, glaucoma and the occurrence of cancer. Here we show an essential role of
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