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Merck
CN

B013

Sigma-Aldrich

N-(2-氯乙基-N-乙基-2-甲基苄胺 盐酸盐

solid

别名:

2-CEA, N-乙基-N-(2-氯乙基)-2-甲基苄胺 盐酸盐, Xylamine 盐酸盐

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关于此项目

经验公式（希尔记法）:
C12H18ClN · HCl
化学文摘社编号:
57913-68-5
分子量:
248.19
MDL编号:
MFCD00043240
UNSPSC代码:
12352103

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表单

solid

颜色

white

溶解性

H2O: soluble
ethanol: soluble
methanol: soluble

SMILES字符串

Cl.CCN(CCCl)Cc1ccccc1C

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生化/生理作用

去甲肾上腺素向中枢和外周神经元转运的选择性、不可逆阻断剂。

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B A Faraj et al.
Pharmacology, 48(5), 320-327 (1994-05-01)
The main objective of the present investigation was to determine whether the uptake of [3H]-dopamine in human lymphocytes is mediated through a serotonin transporter. This was examined by studying the effects of various monoamine uptake inhibitors on the uptake of
J B Fischer et al.
The Journal of pharmacology and experimental therapeutics, 226(3), 650-655 (1983-09-01)
The accumulation of tritium-labeled xylamine ([3H]XYL), an irreversible inhibitor of neuronal norepinephrine (NE) uptake, was studied in organ-cultured rat superior cervical ganglia (SCG). At concentrations below those which significantly inhibit NE uptake, [3H]XYL accumulation was linear with time for up
T K Chang et al.
Brain research, 597(1), 162-165 (1992-11-27)
Primary astrocyte cultures from neonatal rat brains show a Na+-dependent, desipramine-sensitive uptake of [3H]norepinephrine ([3H]NE). Xylamine, a nitrogen mustard, attenuated this uptake of [3H]NE into the astrocytes (IC50 = 0.8 microM). The dose-dependent reduction of [3H]NE uptake by xylamine indicated
R W Ransom et al.
Life sciences, 37(13), 1177-1182 (1985-09-30)
Xylamine (XYL) administered to intact rats caused a 70-80% reduction in norepinephrine (NE) uptake by the vas deferens but had little or no effect on NE content in that tissue. The vas deferens accumulates 3H-XYL in vitro by a desmethylimipramine
Y Huang
European journal of pharmacology, 327(1), 41-47 (1997-05-26)
The effects of noradrenaline uptake inhibitors on contractions evoked by electric field stimulation, noradrenaline, clonidine. 5-hydroxytryptamine, ATP, high K+, and BaCl2 in the epididymal half of rat isolated vas deferens were examined. Protriptyline, amitriptyline and xylamine concentration-dependently inhibited monophasic contractions

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