B0560
(−)-II型肌球蛋白
≥98% (HPLC), solid, cell cycle inhibitor
别名:
1-苯基-1,2,3,4-四氢-4-羟基[2,3-B]-7-甲基喹啉-4-酮
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关于此项目
经验公式（希尔记法）:
C18H16N2O2
CAS Number:
分子量:
292.33
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
(−)-II型肌球蛋白, solid, synthetic
质量水平
表单
solid
溶解性
DMSO: 5 mg/mL
chloroform: soluble(lit.)
ethyl acetate: soluble(lit.)
methanol: soluble(lit.)
methylene chloride: soluble(lit.)
储存温度
−20°C
SMILES字符串
Cc1ccc2N=C3N(CC[C@@]3(O)C(=O)c2c1)c4ccccc4
InChI
1S/C18H16N2O2/c1-12-7-8-15-14(11-12)16(21)18(22)9-10-20(17(18)19-15)13-5-3-2-4-6-13/h2-8,11,22H,9-10H2,1H3/t18-/m1/s1
InChI key
LZAXPYOBKSJSEX-GOSISDBHSA-N
相关类别
一般描述
(-)-布雷他汀是一种生物活性小分子，是骨骼肌和非肌肉肌球蛋白II亚型的选择性抑制剂。布雷他汀，一种II型肌球蛋白ATP酶抑制剂，不影响I、V和X型等肌球蛋白超家族的其它成员。布雷他汀对光十分敏感，并且光漂白可以完全逆转其效果。布雷他汀是一种心血管生理学中常用的激发-收缩解偶联剂。布雷他汀可控制凝血酶对细胞间Ca2+波传播的抑制作用。布雷他汀通过稳定粗肌丝的静息状态来抑制心肌收缩。布雷他汀对多种肌球蛋白II的选择性与亲和性令其成为细胞迁移和肌肉生理学研究的有吸引力候选者。
应用
(?)-布雷他汀已被用于研究对心肌收缩力的影响 以及凝血酶对肌动球蛋白收缩性的影响
生化/生理作用
(-)-布雷他汀是一种细胞周期抑制剂；非肌肉II型肌球蛋白的选择性抑制剂。
特点和优势
该化合物是细胞凋亡研究的推荐产品。点击此处，了解更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Application of blebbistatin as an excitation-contraction uncoupler for electrophysiologic study of rat and rabbit hearts
Fedorov VV, et al.
Heart Rhythm : the Official Journal of the Heart Rhythm Society, 4(5), 619-626 (2007)
Valerie C Coffman et al.
Molecular biology of the cell, 20(24), 5195-5210 (2009-10-30)
Two prevailing models have emerged to explain the mechanism of contractile-ring assembly during cytokinesis in the fission yeast Schizosaccharomyces pombe: the spot/leading cable model and the search, capture, pull, and release (SCPR) model. We tested some of the basic assumptions
Elena Kassianidou et al.
Cell reports, 27(6), 1897-1909 (2019-05-09)
Three-dimensional matrices often contain highly structured adhesive tracks that require cells to turn corners and bridge non-adhesive areas. Here, we investigate these complex processes using micropatterned cell adhesive frames. Spreading kinetics on these matrices depend strongly on initial adhesive position
The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellular calcium wave propagation in corneal endothelial cells
Ponsaerts R, et al.
Investigative Ophthalmology & Visual Science, 49(11), 4816-4827 (2008)
Blebbistatin: use as inhibitor of muscle contraction
Farman GP, et al.
Pflugers Archiv : European Journal of Physiology, 455(6), 995-1005 (2008)
商品
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
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