BMP-7 active human

The biological activity of BMP-7 is measured by its ability to induce alkaline phosphatase production by ATDC5 cells.
ED₅₀: ≤ 40 ng/mL

The bone morphogenetic proteins are a family of secreted signaling molecules that can induce ectopic bone growth. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP1), is a widely expressed TGFb superfamily member with important functions during embryogenesis, in the adult, and in disease (Chen et al., 2004, Kishigami and Mishina 2005). BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (Sampath et al., 1992, Kazama et al., 2008), inhibits the branching of prostate epithelium (Grishina et al., 2005), and antagonizes epithelialmesenchymal transition (Zeisberg et al., 2003, Yu et al., 2009). In pathological conditions, BMP7 inhibits tumor growth and metastasis (Buijs et al., 2007), ameliorates fibrotic damage in nephritis (Zeisberg et al., 2003), and promotes neuroregeneration following brain ischemia (Chou et al., 2006).

Extinction Coefficient: E^0.1% = 1.321 (A ₂₈₀ nm)

Lyophilized from a Tris HCl 0.05 M buffer at pH 7.4

Lyophilized protein should be reconstituted in water to a concentration of 50 ng /μl.