B102
安非他酮 盐酸盐
≥98% (HPLC), solid, dopamine and norepinephrine transporter inhibitor
别名:
（±）-1-（3-氯苯基）-2-[（1,1-二甲基乙基）氨基]-1-丙酮 盐酸盐
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选择规格
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关于此项目
经验公式（希尔记法）:
C13H18ClNO · HCl
化学文摘社编号:
分子量:
276.20
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
250-759-9
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
产品名称
安非他酮 盐酸盐, ≥98% (HPLC), solid
description
Drug Control: Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet
Quality Segment
assay
≥98% (HPLC)
form
solid
drug control
Kábítószer / Narcotic Drug (Hungary), 78/2022. (XII. 28.) BM rendelet
color
white
solubility
H2O: 15 mg/mL, clear
originator
GlaxoSmithKline
SMILES string
Cl[H].CC(NC(C)(C)C)C(=O)c1cccc(Cl)c1
InChI
1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H
InChI key
HEYVINCGKDONRU-UHFFFAOYSA-N
Gene Information
human ... DRD1(1812), DRD2(1813), DRD3(1814), DRD4(1815), DRD5(1816), SLC6A2(6530), SLC6A3(6531)
General description
Bupropion is structurally linked to the phenylethylamine family. It is a monocyclic aminoketone (chloropropiophenone).
Application
Bupropion hydrochloride has been used as an anti-depressant and injected into mice intraperitoneally for forced swim test. It has also been used to study its effects on depression, anxiety and smoking cessation.
Biochem/physiol Actions
Bupropion possesses antidepressant and anxiolytic properties. It serves as a good auxiliary for people who makes an effort to give up smoking. It may also be used in the treatment for attention-deficit hyperactivity disorder.
Inhibits the dopamine and norepinephrine transporters with Kis of 2.8 μM and 1.4 μM, respectively. Does not inhibit the serotonin transporter (Ki = 45 μM). Antidepressant.
Features and Benefits
This compound is a featured product for ADME Tox and Neuroscience research. Discover more featured ADME Tox and Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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