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B1152

Betamethasone 17,21-dipropionate

Name: Betamethasone 17,21-dipropionate
Brand: SIGMA

≥97.0%, glucocorticoid, powder

别名:

9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 17,21-dipropionate

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关于此项目

经验公式（希尔记法）:

C₂₈H₃₇FO₇

化学文摘社编号:

5593-20-4

分子量:

504.59

NACRES:

NA.77

PubChem Substance ID:

24891564

UNSPSC Code:

12352200

EC Number:

227-005-2

MDL number:

MFCD00133140

Assay:

≥97.0%

Form:

powder

Quality level:

200

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产品名称

Betamethasone 17,21-dipropionate,

assay

≥97.0%

Quality Level

200

form

powder

originator

Schering Plough

SMILES string

[H][C@@]12C[C@H](C)[C@](OC(=O)CCl)(C(=O)COC(=O)CC)[C@@]1(C)C[C@H](O)C3(F)[C@@]2([H])CCC4=CC(=O)C=C[C@]34C

InChI

1S/C27H34ClFO7/c1-5-22(33)35-14-21(32)27(36-23(34)13-28)15(2)10-19-18-7-6-16-11-17(30)8-9-24(16,3)26(18,29)20(31)12-25(19,27)4/h8-9,11,15,18-20,31H,5-7,10,12-14H2,1-4H3/t15-,18-,19-,20-,24-,25-,26?,27-/m0/s1

InChI key

UOCNBCVPZWLUKX-HOBFILNXSA-N

General description

Betamethasone dipropionate is a class III intermediate potency synthetic fluorinated corticosteroid, which is used to treat psoriasis vulgaris. It is also used to treat seborrheic dermatitis and chronic hand eczema.

Biochem/physiol Actions

Betamethasone 17,21-dipropionate is a glucocorticoid with anti-inflammatory and immunosuppressive activity.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

GHS08

signalword

Danger

hcodes

H360FD,H373

pcodes

P202 - P260 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B - STOT RE 2

target_organs

Liver,Kidney,Endocrine system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Seborrheic dermatitis

Gupta AK and Bluhm R

Journal of the European Academy of Dermatology and Venereology : JEADV, 18(1), 13-26 (2004)

Comparison of cyclosporine and topical betamethasone-17, 21-dipropionate in the treatment of severe chronic hand eczema.

Granlund H, et al.

Acta Dermato-Venereologica, 76(5), 371-376 (1996)

Use of a psoriasis plaque test in the development of a gel formulation of calcipotriol and betamethasone dipropionate for scalp psoriasis.

Catherine Queille-Roussel et al.

The Journal of dermatological treatment, 24(4), 250-254 (2011-11-23)

The efficacy and safety of calcipotriol plus betamethasone dipropionate ointment in the treatment of psoriasis vulgaris has consistently been demonstrated in several clinical trials. For treatment of scalp psoriasis, more convenient formulations are required. Therefore, new lipophilic alcohol-free gel formulations

Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis

Papp KA, et al.

Journal of the American Academy of Dermatology, 48(1), 48-54 (2003)

The effects of betamethasone dipropionate and fish oil on HaCaT proliferation and apoptosis.

Mohd Hanif Zulfakar et al.

International journal of pharmaceutics, 434(1-2), 399-405 (2012-06-14)

The current work examined the effect of fish oil (FO) and betamethasone dipropionate (BD) on the growth of immortalized HaCaT keratinocytes. HaCaT cells were grown and treated with FO and/or BD, and proliferation determined using the MTT method. The cells

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全球贸易项目编号

货号	GTIN
B1152-1G	04061833421185
B1152-100MG	04061832852799
B1152-500MG	04061832852805

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