B133
（S）-（−）-Bay K8644
≥98% (HPLC), Ca2+ channel activator, solid
别名:
S-（−）-1，4-二氢-2，6-二甲基-5-硝基-4-[2-（三氟甲基）苯基]-3-吡啶甲酸甲酯
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关于此项目
经验公式（希尔记法）:
C16H15F3N2O4
化学文摘社编号:
分子量:
356.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
（S）-（−）-Bay K8644, ≥98% (HPLC), solid
SMILES string
COC(=O)C1=C(C)NC(C)=C([C@H]1c2ccccc2C(F)(F)F)[N+]([O-])=O
InChI
1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
InChI key
ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
assay
≥98% (HPLC)
form
solid
color
yellow
solubility
H2O: slightly soluble
ethanol: soluble (Organic solutions are stable for at least 20 days at RT.)
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADORA3(140)
rat ... Adora1(29290), Adora2a(25369)
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Application
（S）-（-）-Bay K8644已被用作视交叉上核（SCN）切片中的L型钙通道（LTCC）激动剂。它也被用作LTCC激动剂以诱导大鼠心律失常。
Biochem/physiol Actions
（S）-（-）-Bay K8644增强Ca2+电流，而（+）-Bay K 8644是弱Ca2+通道拮抗剂。Bay K 8644具有亲脂性，可有效清除超氧阴离子。
General description
（S）-（-）-Bay K8644，一种二氢吡啶化合物，是一种Ca2+ 通道激活剂。它是Bay K 8644的对映异构体。
Legal Information
经Bayer AG许可生产和销售。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Joshua P Whitt et al.
The Journal of general physiology, 150(2), 259-275 (2017-12-15)
Large conductance K+ (BK) channels are expressed widely in neurons, where their activation is regulated by membrane depolarization and intracellular Ca2+ (Ca2+i). To enable this regulation, BK channels functionally couple to both voltage-gated Ca2+ channels (VGCCs) and channels mediating Ca2+
Gildenisson Araújo do Nascimento et al.
Arquivos brasileiros de cardiologia, 113(5), 925-932 (2019-09-05)
D-limonene (DL) is a monoterpene and is the major component in the essential oil of citrus fruit. It presents antihyperglycemic and vasodilatation activities. This study evaluated the cardiovascular effects and potential antiarrhythmic of DL in rats. Hemodynamic and electrocardiographic (ECG)
J J Enyeart et al.
Molecular endocrinology (Baltimore, Md.), 4(5), 727-735 (1990-05-01)
Dihydropyridine (DHP) Ca2+ channel modulators were used to explore the relationship between voltage-gated Ca2+ channels and PRL secretion, synthesis, and mRNA in PRL-secreting pituitary cells. Optical isomers of the Ca2+ channel agonist Bay K 8644 produced stereospecific and opposing effects
Paula Clancy et al.
Journal of atherosclerosis and thrombosis, 23(7), 773-791 (2016-03-08)
Matrix metalloproteinases (MMPs), angiotensin II (AII) and its receptors are implicated in atherosclerotic plaque instability, however the roles of the two receptor subtypes, ATR1 and ATR2, in MMP regulation remain uncertain. In this study, we investigated the effect of ATR1
J Ferrante et al.
Biochemical and biophysical research communications, 158(1), 149-154 (1989-01-16)
The 1,4-dihydropyridine Ca2+ channel activator, (-) [3H]Bay K 8644, binds to cardiac membranes and polarized [5 mM K+] and depolarized [50 mM K+] cardiac cells. Binding to microsomal membranes at 25 degrees C indicates a single set of binding sites
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