B1401
缓激肽片段 1-5
≥97% (HPLC)
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经验公式（希尔记法）:
C27H40N8O6
化学文摘社编号:
分子量:
572.66
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
powder
Assay:
≥97% (HPLC)
InChI
1S/C27H40N8O6/c28-18(9-4-12-31-27(29)30)24(38)35-14-6-11-21(35)25(39)34-13-5-10-20(34)23(37)32-16-22(36)33-19(26(40)41)15-17-7-2-1-3-8-17/h1-3,7-8,18-21H,4-6,9-16,28H2,(H,32,37)(H,33,36)(H,40,41)(H4,29,30,31)
SMILES string
NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(O)=O
InChI key
USSUMSBPLJWFSZ-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
Quality Level
Gene Information
human ... KNG1 (includes EG:3827)
storage temp.
−20°C
Biochem/physiol Actions
缓激肽(BK)片段(1-5)(RPPGF)是最稳定的天然代谢产物之一。可作为体内缓激肽产生的标志物。其生物活性依赖于C末端的一个完整的精氨酸(Arg)残基。BK 1-5是抑制α-凝血酶诱导的血小板聚集和分泌及钙离子动员的必需肽。还可抑制α-凝血酶在精氨酸和丝氨酸之间的位点切割凝血酶受体肽NATLDPRSFLLR。BK 1-5的这种抗凝血酶活性可能与激肽的心脏保护作用有关。
Packaging
无底玻璃瓶。内含物装在锥底内插管中。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
S A Doggrell
Expert opinion on investigational drugs, 10(8), 1567-1569 (2002-01-12)
When the defence response of the body to infectious bacteria fails, septic shock ensues with hypotension and death. RPPGF,(1-5)-bradykinin, was until recently considered to be an active metabolite of bradykinin. In an animal model of septicaemia (lipopolysaccharide administration to rats)
Mitsuhiro Hirata et al.
British journal of pharmacology, 135(1), 29-36 (2002-01-12)
1. The involvement of bradykinin (BK) B(2) receptor in acute pancreatitis induced by pancreaticobiliary duct ligation was investigated in rats. 2. The activities of amylase and lipase in the serum, the water content of the pancreas, and vacuolization of the
Mias Pretorius et al.
Clinical pharmacology and therapeutics, 76(4), 379-387 (2004-10-08)
This study tested the hypothesis that angiotensin-converting enzyme (ACE) inhibitors potentiate activation of the kallikrein-kinin system during cardiopulmonary bypass (CPB). The effects of CPB on concentrations of bradykinin and its metabolite bradykinin 1-5 (BK1-5) were determined in 31 patients taking
Beata Bujak-Giżycka et al.
Acta biochimica Polonica, 58(2), 199-202 (2011-05-31)
Alterations in the formation and metabolism of bradykinin (Bk) are hypothesized to play a role in the pathophysiology of hypertension, atherosclerosis and vascular complications of diabetes. However, despite its prominent role in cardiovascular regulation, studies on bradykinin have been limited
M Cugno et al.
Clinical science (London, England : 1979), 101(6), 651-657 (2001-11-29)
Bradykinin, a nonapeptide with vasodilatory and permeabilizing activity, is generated through the cleavage of high-M(r) ('high-molecular-weight') kininogen by kallikrein, and its generation is facilitated by plasmin. In the ascitic fluid of patients with cirrhosis, there is massive cleavage of high-M(r)
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