B1427
H-89 二盐酸盐 水合物
≥98% (HPLC), powder, PKA inhibitor
别名:
N-[2-（对溴肉桂胺基）乙基]-5-异喹啉磺胺 二盐酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C20H20BrN3O2S · 2HCl · xH2O
化学文摘社编号:
分子量:
519.28 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
H-89 二盐酸盐 水合物, ≥98% (HPLC), powder
color
off-white
SMILES string
O.Cl.Cl.Brc1ccc(\C=C\CNCCNS(=O)(=O)c2cccc3cnccc23)cc1
InChI
1S/C20H20BrN3O2S.2ClH.H2O/c21-18-8-6-16(7-9-18)3-2-11-22-13-14-24-27(25,26)20-5-1-4-17-15-23-12-10-19(17)20;;;/h1-10,12,15,22,24H,11,13-14H2;2*1H;1H2/b3-2+;;;
InChI key
GKFFJFGBWAGAFD-HZBIHQSRSA-N
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
powder
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
Quality Level
Gene Information
human ... PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
Application
H-89二盐酸盐水合物抑制蛋白激酶A，用于Leydig细胞、 原代颅骨成骨细胞（pOB）、 大鼠颗粒细胞系（LH-15细胞） 和人脐静脉内皮细胞（HUVEC）。
Biochem/physiol Actions
H-89二盐酸盐水合物是蛋白激酶A（PKA）选择性抑制剂。也能抑制大鼠肌细胞中的钾（K+）电流。它与上皮Na+ 通道（ENaC）的 α 亚基相互作用，介导Na+ 转运。
其具有选择性，是cAMP依赖性蛋白激酶有效抑制剂。
Features and Benefits
该化合物是激酶磷酸酶生物学研究的推荐产品。点击这里 发现更多精选激酶磷酸酶生物学产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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