B1651
缓激肽片段 1-7
≥97% (HPLC)
别名:
1-7-Bradykinin
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选择尺寸
关于此项目
经验公式（希尔记法）:
C35H52N10O9
化学文摘社编号:
分子量:
756.85
MDL编号:
UNSPSC代码:
12352209
PubChem化学物质编号:
NACRES:
NA.26
产品名称
缓激肽片段 1-7, ≥97% (HPLC)
质量水平
方案
≥97% (HPLC)
表单
powder
颜色
white
UniProt登记号
储存温度
−20°C
SMILES字符串
NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(O)=O
InChI
1S/C35H52N10O9/c36-22(10-4-14-39-35(37)38)31(50)44-16-6-12-26(44)33(52)43-15-5-11-25(43)30(49)40-19-28(47)41-23(18-21-8-2-1-3-9-21)29(48)42-24(20-46)32(51)45-17-7-13-27(45)34(53)54/h1-3,8-9,22-27,46H,4-7,10-20,36H2,(H,40,49)(H,41,47)(H,42,48)(H,53,54)(H4,37,38,39)
InChI key
CRROPKNGCGVIOG-UHFFFAOYSA-N
基因信息
rat ... Nppa(24602)
Amino Acid Sequence
Arg-Pro-Pro-Gly-Phe-Ser-Pro
一般描述
缓激肽片段1-7（BK-(1-7)）是一种内源性肽，存在于血浆中。
应用
缓激肽片段1-7已被用作基质辅助激光解吸电离飞行时间质谱法（MALDI-TOF MS）蛋白质斑点分析中的外部校准物/标准品。
缓激肽片段1-7用于激肽酶的特异性和动力学研究。
生化/生理作用
缓激肽（BK）是一种促炎介质和神经介质。它可以调节多种血管和肾脏功能。缓激肽（BK）在诱导血管通透性和有丝分裂中起关键作用。它有助于在炎症和癌症组织中释放一氧化氮。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
M Simmaco et al.
Biochimica et biophysica acta, 1033(3), 318-323 (1990-03-26)
The peptide fraction extracted by methanol from the skin of Rana esculenta, a species widely distributed in Western Europe, was investigated. The pharmacological activity found in the extract is attributable to the presence of authentic bradykinin, together with a shorter
Darren Greetham et al.
Proteomics, 4(7), 1989-1995 (2004-06-29)
Phage display techniques using random peptide interactions have supported the role of mammalian glutathione transferase (GST) as part of a signalling pathway for both oxidative stress and an apoptosis pathway. Little is known about the interaction of nonmammalian GST with
L Germain et al.
Journal of neuroimmunology, 13(2), 135-142 (1986-12-01)
The pathology of acute experimental allergic encephalomyelitis is characterized by perivascular cellular infiltrates in the central nervous system. Our hypothesis is that this immuno-pharmacological process can activate the circulating and tissular kallikrein-kinin systems. We studied 21 New Zealand rabbits inoculated
C Shima et al.
Japanese journal of pharmacology, 60(2), 111-119 (1992-10-01)
Degradation of bradykinin (BK) in human plasma was investigated by searching for a stable metabolite as a marker of kinin release in vivo. BK, incubated with diluted plasma, was degraded to des-Arg9-BK (des-9-BK), des-Phe8-Arg9-BK (des-8,9-BK) and Arg-Pro-Pro-Gly-Phe ([1-5]BK). Des-9-BK was
M Katori et al.
British journal of pharmacology, 98(4), 1383-1391 (1989-12-01)
1. In vitro incubation of normal rat plasma with endotoxin from E. coli (3-10 mg ml-1) in the incubation mixture) caused a dose-dependent increase in levels of free kinin and plasma kallikrein in the presence of o-phenanthroline, together with a
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