B1651
缓激肽片段 1-7
≥97% (HPLC)
别名:
1-7-Bradykinin
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关于此项目
经验公式（希尔记法）:
C35H52N10O9
化学文摘社编号:
分子量:
756.85
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
产品名称
缓激肽片段 1-7, ≥97% (HPLC)
SMILES string
NC(CCCNC(N)=N)C(=O)N1CCCC1C(=O)N2CCCC2C(=O)NCC(=O)NC(Cc3ccccc3)C(=O)NC(CO)C(=O)N4CCCC4C(O)=O
InChI
1S/C35H52N10O9/c36-22(10-4-14-39-35(37)38)31(50)44-16-6-12-26(44)33(52)43-15-5-11-25(43)30(49)40-19-28(47)41-23(18-21-8-2-1-3-9-21)29(48)42-24(20-46)32(51)45-17-7-13-27(45)34(53)54/h1-3,8-9,22-27,46H,4-7,10-20,36H2,(H,40,49)(H,41,47)(H,42,48)(H,53,54)(H4,37,38,39)
InChI key
CRROPKNGCGVIOG-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
color
white
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
rat ... Nppa(24602)
General description
缓激肽片段1-7（BK-(1-7)）是一种内源性肽，存在于血浆中。
Application
缓激肽片段1-7已被用作基质辅助激光解吸电离飞行时间质谱法（MALDI-TOF MS）蛋白质斑点分析中的外部校准物/标准品。
缓激肽片段1-7用于激肽酶的特异性和动力学研究。
Biochem/physiol Actions
缓激肽（BK）是一种促炎介质和神经介质。它可以调节多种血管和肾脏功能。缓激肽（BK）在诱导血管通透性和有丝分裂中起关键作用。它有助于在炎症和癌症组织中释放一氧化氮。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Laura M Jones et al.
Journal of proteome research, 9(6), 2871-2881 (2010-04-16)
The insulin/insulin-like growth factor-1 (IGF-1) signaling system is a public regulator of aging in the model animals Caenorhabditis elegans, Drosophila melanogaster, and Mus musculus. For the first time, proteomic analyses of the environmentally resistant and 'nonaging' C. elegans dauer stage
J M Ribeiro et al.
Experimental parasitology, 89(2), 213-221 (1998-06-27)
Saliva and salivary gland homogenates of Ixodes scapularis contain a dipeptidyl carboxypeptidase activity that accounts for the previously described salivary kininase activity of this tick. Reversed phase HPLC and laser desorption mass spectrography of the reaction products identified bradykinin fragment
Peptide fragments of bradykinin show unexpected biological activity not mediated by B1 or B2 receptors
Souza SI, et al.
15th international conference on miniaturized systems for chemistry and life sciences, Seattle, Washington (2021)
M Bramucci et al.
Acta physiologica Scandinavica, 175(2), 123-128 (2002-05-25)
Angiotensin converting enzyme (ACE) was demonstrated to modulate the production of 17beta-estradiol, progesterone and prostaglandin E2 (PGE2) in frog ovary of Rana esculenta. However, the activity was not mediated by angiotensin II (Ang II). In an attempt to identify the
Measurement of des-Phe8-Arg9-bradykinin by enzyme-immunoassay--a useful parameter of plasma kinin release.
M Majima et al.
Advances in experimental medicine and biology, 247B, 331-335 (1989-01-01)
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